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Biomedical subjects

Z Stanković

Publications and source records attributed to Z Stanković.

8 recordsLinked to original sources
PubMed2006

Validation of a high-performance liquid chromatographic method for the simultaneous determination of tramadol and its impurities in oral drops as a pharmaceutical formulation.

The novel, rapid high performance liquid chromatographic method for the determination of tramadol hydrochloride and its three impurities was developed and validated. The method can simultaneously assay potassium sorbate, used as preservative, and saccharin sodium, used as sweetener in tramadol pharmaceutical formulation. The separation was carried out on a C(18) XTerra (150 mm x 4.6 mm, 5 mm) column using acetonitrile-0.015 M Na(2)HPO(4) buffer (2:8, v/v) as mobile phase (pH value 3.0 was adjusted with orthophosphoric acid) at a flow rate 1.0 ml min(-1), temperature of the column 20 degrees C and UV detection at 218 nm. The method was found to be linear (r > 0.999) in the range of 0.05-0.8 mg ml(-1) for tramadol hydrochloride, 0.1-1.2 mg ml(-1) for impurities B and C and for impurity A (r > 0.995) in the range 0.15-2.4 mg ml(-1). The low RSD values indicate good precision and high recovery values indicate excellent accuracy of the HPLC method. Developed method was successfully applied to the determination of tramadol hydrochloride, its investigated impurities and potassium sorbate in commercial formulation. The recovery of tramadol hydrochloride was 98.25% and RSD was 1.80%. The method is rapid and sensitive enough to be used to analyse Trodon oral drops.

Chromatography, High Pressure Liquid↗
PubMed1989

[Malignant transformation in bone cysts].

Bone cysts are often found on x-ray examinations of patients in their first two decades of life. We present an extremely rare case of cystically changed first metatarsal bone of the left foot. The content of the cyst was histopathologically verified as consisting of a mixture of echinococcal scolexes and chondrosarcomatous tissue.

Adult↗
PubMedDate not supplied

[Ochronosis--an autopsy case report].

The authors have presented a case of ochronosis, as the incidental finding during the autopsy of a female patient, aged 59 years. It was the case of suicidal drug poisoning. Ochronosis is a rare disease, with chronic benign course, but frequently followed by complications. Histopathological criteria for the diagnosis of this disease are described in detail.

Diazepam↗
PubMedDate not supplied

[Correlation of clinical and autopsy diagnosis during a 10-year period at the Institute for Pathology and Forensic Medicine at the Military Medicine Academy in Belgrade].

The comparison between the clinical and pathohistoanatomic diagnosis of 3.929 autopsied cases is performed. In 82.5% of cases the clinical and pathohistoanatomic diagnosis were in the absolute correlation; in 8% of cases the clinical diagnosis of the basic disease has no adequate pathoanatomic characteristics, while in 4.5% of cases the clinical diagnosis of the basic disease, immediate cause of death and condition which was important for the course and outcome of the treatment were not adequate. Among the pathologic states diagnosed as: pulmonary thromboembolism, myocardial infarction and cerebrovascular insult--pulmonary embolism most often was not confirmed by autopsy (47%), while in 58% of cases it remained clinically unrecognized. Malignant tumours of the liver, pancreas and kidneys have been most frequently clinically unrecognized compared to other malignancies. Duration of hospitalization has not had the essential influence on correct establishment of the clinical diagnosis.

Autopsy↗
PubMedDate not supplied

Forensic-medical expertise of twenty four murdered citizens from Gospić and its surroundings.

The forensic-medical expertise of 24 predominantly carbonized bodies, that were found at Kukin Do was reported. The victims were from Gospić and its surroundings, who disappeared between October 16-18, 1991. The expertise involved the identification of bodies, injury classification, determination of tools by which injuries were inflicted as well as time when injuries were inflicted, and whether it was when the victims were alive or dead. At the time of expertise all bodies were in the state of advanced putrification, frozen and burned. In 18 cases, the larger or smaller parts of bodies lacked as the consequence of fire. Eleven persons were identified as the Serbs from Gospić and for thirteen persons the procedure of identification is still in process. In 21 persons while they were alive, injuries were done with: bullets, blade, pointed and blunt mechanical tools. In three persons, injuries were not found due to missing of the larger parts of bodies. After their death all corpses were burned, and in two persons bites of rodents were evident.

Adult↗
PubMedDate not supplied

[Morphologic characteristics of persons killed in armored vehicles].

The authors have analysed macroscopic and microscopic changes in tissues and organs of 8 members of the Y.P.A. killed by granate explosion in the armoured vehicles. In all the analysed cases multiple mechanic injuries were found as well as combined mechanothermal injuries. Injuries caused by the blast wave were mainly found in the internal air-containing organs and three cases of solid blast injury were described too.

Blast Injuries↗