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Biomedical subjects

Z Szot

Publications and source records attributed to Z Szot.

16 recordsLinked to original sources
PubMed1989

Efficacy and toxicity of N,N',N",N"'-tetra(2,3,4-trihydroxybenzoyl)-spermine for decorporation of 239Pu from mice.

Male SAS/4 mice were injected i.v. with 6.6 kBq 239Pu-citrate. After 1 or 24 h a single i.p. injection of 15 or 30 mumol kg-1 or repeated (three or four) daily injections of 30 mumol kg-1 of tetra-THB-spermine were given, and at 4 or 7 days Pu retention was measured in liver, kidneys and femur. Besides tetra-THB-spermine, equimolar doses of tetra-DHB-spermine were injected for comparison, or equimolar doses of diethylene triamine-pentaacetic acid (DTPA) as a reference compound. Histological changes in kidneys and liver were examined after i.p. injections of 30 mumol kg-1 or at 2-13 times higher doses of tetra-THB-spermine. The results show that: (1) Introduction of an additional hydroxy group into the aromatic moieties of tetra-DHB-spermine results in increased hydrophilicity, lower toxicity and a lower renal retention of Pu. (2) Tetra-THB-spermine and tetra-DHB-spermine are similarly effective in removing plutonium from liver and bone. Their efficacies in removing Pu from bone are approximately similar to those of DTPA but for whole-body removal they are generally inferior. (3) Multiple (30 mumol kg-1) of tetra-THB-spermine were no more effective than a single injection at mobilizing Pu from the liver. (4) Four injections of tetra-THB-spermine induced cloudy swelling and fatty degeneration in epithelial cells of the proximal convoluted tubules. At levels of 400 mumol kg-1 tetra-THB-spermine produced severe degenerative glomerular lesions, foci of liver necrosis and thromboses of the portal vein branch.

Animals↗
PubMed1986

Removal of 239Pu from mice with 3,4,3 LICAM(C) or N,N',N'',N'''-tetra-(2,3-dihydroxybenzoyl)-spermine.

Male mice SAS/4 were injected i.v. with 239Pu citr(IV) 0.27 microCi . kg-1-9.99 kBq X kg-1. After 1 h 30 mumol . kg-1 of 3,4,3 LICAM(C), N,N',N'',N'''-tetra-(2,3-dihydroxybenzoyl)-spermine or Na3CaDTPA as a reference compound was given intraperitoneally. After 4 days the animals were sacrificed and the Pu content in livers, kidneys, femurs and carcasses was determined by the liquid scintillation method. It was found that, as compared with the control, 3,4,3 LICAM(C) removed 83% of the Pu activity deposited in the liver, 71% of that in the femur and 79% of the Pu in the whole body. The Pu content in the kidneys exceeded the control value by about 50%. Na3CaDTPA removed 96, 86, 40 and 72% of plutonium from the liver, kidneys, femurs and carcasses respectively. Tetra-DHB-spermine caused the excretion of 50, 57 and 39% of Pu from liver, bone and whole body respectively. The retention of Pu in the kidneys was increased to 400% of the control value.

Animals↗
PubMed1985

Overloading changes in the motor system occurring in elite gymnasts.

Top-level gymnasts were examined in 1976 and in 1980. During both examinations X-ray osteal changes as a result of training were found. In 1980 complaints of pain during the training process were analyzed. It was found that radiological changes appeared in the elbow joints (73.2%), spinal column (65.8%), in the area of the shoulder joints (59.8%), and in the wrist joints (58.5%). The L-S segment of the spinal column had such anomalies as schistorrhachis of the S1 arc, lumbarization, and sacralization. A characteristic feature was the frequent discrepancy between complaints of pain and radiological changes. In many cases permanent radiological changes were not accompanied by pain. Longer training periods were associated with more pronounced changes. It was concluded that radiological examinations should be one of the criteria for selecting gymnasts and a change in the FIG regulations is proposed to reduce the work load of the motor system.

Adolescent↗
PubMed1975

Effects of DTPA on the deposition of 65Zn, 60Co and 144Ce in pregnant rat and in foetoplacental unit.

65Zn, 60Co or 144Ce was injected intravenously into rats at various stages of pregnancy. Six hours later, DTPA chelate of non-radioactive Ca, Zn or Co was given intraperitoneally. Another group of pregnant rats received intravenous injection of 65ZnDTPA or 60CoDTPA. In both experiments, 24 hours after administration, the concentration of the radioactive material was determined in the dam's whole body as well as in foetuses, chorioallantoic placentae and yolk sacs. 65Zn and 60Co, which had been administered to the rats as DTPA complexes, were found not to pass from the dam's blood to the foetuses or to pass only in very minute amounts. This finding could be considered as an indirect indication that DTPA chelates do not penetrate the placental barrier. Nevertheless, the chelates injected intravenously into the dam early after an internal contamination, decrease the radionuclide content in the foetuses. No substantial effects of pregnancy on the effectiveness of the chelate in removing radionuclides from the body of rats were observed.

Animals↗