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Biomedical subjects

Z Tóth

Publications and source records attributed to Z Tóth.

At least 55 records · Page 3Linked to original sources
PubMed1991

Familial occurrence of bilateral renal agenesis.

The 58 cases of bilateral renal agenesis (Potter syndrome) registered in the Genetic Counselling unit of our institute in the last 12 years are reviewed. The only familial recurrent case which has been prenatally diagnosed is described in detail. A urinary bladder anomaly like that of the subsequent third child has not been previously reported. The authors analyze the possible inheritance patterns. They suggest the malformation is a genetically heterogeneous entity. They emphasize that nowadays the birth of a newborn with bilateral renal agenesis can be prevented in all cases.

Congenital Abnormalities↗
PubMed1990

[In utero creation of a reno-amniotic shunt for the preservation of a hydronephrotic fetal kidney].

The authors wish to discuss the successful decompression treatment of a serious, fast progressing one-sided hydronephrotic fetal kidney (that also caused deformation of abdominal and thoracic organs) in a 29th week pregnancy. Under the guidance of ultrasonography they created a permanent link between the amniotic cavity in the uterus and the pelvis of the kidney. As a final solution a pyelo-ureteral anastomosis operation was performed on the newborn that was delivered on the 37th gestational week. The baby is 11 months old at the moment and both of her two kidneys are functioning perfectly.

Adult↗
PubMed1990

[Familial occurrence of bilateral renal agenesis].

The 58 cases of bilateral renal agenesis (Potter syndrome) registered in the Genetic Counselling of our institute in the last 12 years are reviewed. The only recurrent case which has been prenatally diagnosed is described in details. An urinary bladder anomaly like that of the subsequent child has not been reported in such a family previously. The authors analyze the possible inheritance patterns taking into account the previous references, too. They suggest the malformation is a genetically heterogeneous entity. They emphasize that nowadays the birth of a newborn with bilateral renal agenesis can be prevented in all cases.

Abnormalities, Multiple↗
PubMed1990

Computed tomography controlled aspiration surgery for hypertensive intracerebral hemorrhage. Experience of more than 400 cases.

To overcome the disadvantages of conventional surgery, we developed our own method of computed tomography controlled stereotactic aspiration surgery for hypertensive intracerebral hemorrhage. A new ultrasonic surgical aspirator was also developed to facilitate aspiration of a dense clot in the acute stage. Between 1980 and 1988, 437 patients with hypertensive intracerebral hemorrhage underwent aspiration surgery. Computed tomography controlled stereotactic aspiration surgery can be performed in hematomas of any site or any stage with minimal tissue damage, even in aged patients. Aspiration surgery led to a favorable clinical experience and outcome, especially in the acute stage.

Activities of Daily Living↗
PubMed1990

Ultrasound diagnosis and screening of fetal cystic fibrosis.

By ultrasound examination of high risk pregnancies for cystic fibrosis in some cases echogenic areas and dilated bowels could be demonstrated. These signs could be detected in 75% of those cases where biochemical assay of the amniotic fluid proved the fetus to be affected with cystic fibrosis. Having got these results authors started to look for these signs during the screening of normal pregnancies. Out of 22 thousand screened pregnancies 28 amniocenteses have been performed because of the ultrasound finding and in 18 cases the low microvillar enzyme activity also predicted cystic fibrosis.

Amniotic Fluid↗
PubMed1990

Invasive intrauterine procedures in twin pregnancies discordant for fetal malformation.

Invasive intrauterine procedures in two twin pregnancies for exencephaly and multiple malformations are reported. In the first case, to ensure the development of the normal fetus, selective feticide of the affected fetus was undertaken by transabdominal intracardial injection of 20% NaCl solution. A healthy newborn infant with normal weight and a fetus papyraceus were delivered at term. In the second case, because of monoamnial placentation, the procedure was regarded too dangerous, therefore, only therapeutic amniocentesis was carried out to decrease the volume of amniotic fluid. The fetuses were delivered in the preterm period. The advantages of the procedure of selective feticide developed by the authors are also discussed.

Abortion, Induced↗
PubMed1990

A simple method for measuring lateral flexion of the dorsolumbar spine.

A simple method for measurement of spinal dorsolumbar lateral flexion is described. Measurements performed on 200 healthy 19-year-old men showed that normal lateral flexion was about 10% of body height. The method which requires only a measuring tape correlates well with that recorded by the more sophisticated inclinometer.

Body Height↗
PubMed1989

[Surgical management of uterus bilocularis (the first 40 transabdominal metroplasty procedures)].

Forty patients were diagnosed by hysterosalpingography and/or ultrasound as having septate uterus which were assumed to be responsible for their recurrent abortions (35 cases) or infertility (5 cases). All patients, who have not had children yet, had abdominal metroplasty: 27 became pregnant; of their 37 pregnancies 28 continued to term (all but two with delivery by cesarean section) and 9 aborted including 1 hydatidiform mole and 4 blighted ovum, which were due probably not to uterinal but genetic and/or andrologic causes.

Abdomen↗
PubMed1989

Routine prenatal screening policy of fetal malformations by both maternal serum alpha-fetoprotein and ultrasound in eastern Hungary.

Since January 1979, at our Genetic Counselling Unit in Debrecen all pregnancies at high risk for any reason have been screened sequentially by serum alpha-fetoprotein estimation (at the 16th week) and by ultrasound examination (18th week). This screening policy covered 1200-1500 consultations per year. From July 1983, the same prenatal screening policy has been extended to cover the whole pregnant population of two large counties in Eastern Hungary. In a six-year period over 300 fetal malformations were diagnosed. Details of the screening policy and the main groups of malformations diagnosed prenatally are demonstrated.

Congenital Abnormalities↗
PubMed1989

Changes of acid solubility and fluoride content of the enamel surface in children consuming fluoridated milk.

Changes of the acid solubility and fluoride content of the surface layer of the enamel of the first incisor of seventy-nine 9 to 10-year-old children living in a closed community were measured by the method of enamel biopsy at the 6th and 12th months of the consumption of fluoridated milk. Half-year after the beginning of consumption of fluoridated milk the acid solubility decreased significantly, while one-year-long consumption led to significant increase of the fluoride content of the enamel surface.

Animals↗
PubMed1989

Prenatal diagnosis and management of chondrodysplasias.

Thorough ultrasound examination of fetal limbs and fetal movements allows us to recognize several types of osteochondrodysplasia, both in high risk pregnancies (with a family history of chondrodysplasia) and up on routine screening. Correct diagnosis of growth retardation requires nomograms for bone length, and we have developed our own standards for the humerus, ulna, femur and tibia. Since some types of osteochondrodysplasia are compatible with life and others not, it is important to make the correct diagnosis using several differential diagnostic criteria. Only in this way can we decide the further management of a pregnancy. At our Prenatal Diagnosis Centre 8 cases of osteochondrodysplasia have been diagnosed. We discuss the differential diagnosis and the pregnancy management for some of these cases.

Adult↗
PubMed1989

Some basic features of the pathological and normal motor system studied by chronic deep electrodes.

Our stereotactic experiences in agreement with the literature showed, that different target points could influence the same motor disturbance. To choose the best target point or target point combinations we generally implant the electrodes into VL, Vim, CM, P, dentate nucleus and motor cortex. To ensure the correct sequence of therapeutic lesions we developed an investigation system, taking into consideration the resting and the working state of the motor system. We elicited events centrally (stimulation of the different target points) and peripherally (reflexes) and recorded the evoked potentials at the non-stimulated sites along with the motor and motor modulation effects in the appropriate muscles. The elicited events depend on the site of stimulation and registration and on the state of muscle activity. The centrally and peripherally elicited events influence each other. With our technique the elicited events and their functional dependency is most explicit within the motor system. The results help to explain some basic motor functions and help to answer some of our therapeutic questions.

Athetosis↗
PubMed1988

Heterogeneity and recurrence risk for congenital hydrocephalus (ventriculomegaly): a prospective study.

We report on 261 prospectively ascertained pregnancies studied to determine the recurrence risk of congenital hydrocephalus. Our results suggest that couples who have had one previous child with hydrocephalus have a recurrence risk of 4%. Such couples should be offered prenatal diagnosis in the second trimester of all subsequent pregnancies. It is suggested that, apart from the X-linked recessive cases, ventriculomegaly is mostly multifactorially determined.

Genetic Counseling↗
PubMed1988

Relationship between placentation and maternal serum alpha-fetoprotein in twin pregnancies.

Maternal serum alpha-fetoprotein (MSAFP) concentration is raised in twin pregnancies during the second trimester. The approximate doubling of seAFP level in uncomplicated twin pregnancies seems logical, considering the doubled fetal source of AFP, even though the seAFP level is not always increased in twin pregnancies. What factors can influence this phenomenon? With this in mind, we have examined the seAFP concentration in 90 successive twin pregnancies with known outcome. The relationship between seAFP level and the type of placentation is demonstrated.

Birth Weight↗
PubMed1988

Pathological consequences of the vanishing twin.

Fetus papyraceus is a mummified, compressed fetus occurring in association with a viable twin. The death of the fetus usually occurs early in the second trimester. A co-twin dying earlier may be absorbed completely, whilst later fetal death usually results in macerated, but not compressed fetuses. This course of events can be well demonstrated by ultrasonography. The death of one fetuses may be associated with minor malformations of the surviving one. After termination of twin pregnancies the detailed check-up of the newborn and histopathological examination of the placenta is essential.

Female↗
PubMed1988

Prenatal diagnosis by ultrasound of midface defects associated with holoprosencephaly.

Authors present cases of cyclopia, cebocephaly associated with holoprosencephaly, diagnosed prenatally by ultrasound. A detailed description of ultrasound findings is given. When intracranial anatomy appears abnormal, the orbits must be visualized, the interorbital diameter must be measured and facial malformations should be looked for.

Abnormalities, Multiple↗