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Biomedical subjects

Z V Kuropteva

Publications and source records attributed to Z V Kuropteva.

At least 19 recordsLinked to original sources
PubMed2006

[The influence of the bioflanoid dicvertin on the antioxidative system ceruloplasmin-transferrin and lipid peroxidation in patients suffering from stable coronary heart disease with dyslipidemia].

Thirty-two patients with coronary heart disease (CHD)--exertional angina and postinfarction cardiosclerosis with dislipidemia--were treated with dicvertin (2,3-dihydro-3,5,7-trihydroxi-2(3,4-dihydroxiphenyl)-4H-1-benzopyran-4-on), a Russian antioxidant, during two months in a day dose of 80 mg in addition to conventional cardial therapy. The therapy resulted in positive changes including improvement of CHD clinical picture and biochemical serum indices, such as a 6% decrease in cholesterol level, a 12% decrease in low-density lipoproteins cholesterol level, and a 14% increase in high-density lipoproteins cholesterol level. The intensity of lipid peroxidation decreased, the levels of diene conjugates and TBA-reactive products lowered by 38% and 40%, respectively. The fibrinogen level lowered by 20%. The antioxidative status of the patients increased.

Antioxidants↗
PubMed2005

[Effects of mexidol on the antioxidative status of patients suffering from coronary heart disease with dislipidemia].

The subjects of the study were 36 patients suffering from coronary heart disease with exertional angina and postinfarction cardiosclerosis with dislipidemia. The patients were administered mexidol (2-ethyl-6-methyl-3-oxipyridin succinate), a domestically produced antioxidative agent, for 1 month in a dose of 325 mg/day together with conventional cardial therapy. The result was good and included clinical improvements and improvements in biochemical serum parameters: cholesterol level decreased by 10%, the level of low density lipoprotein cholesterol decreased by 25%, high density cholesterol level elevated by 15%. The intensity of lipid peroxidation lowered, which was manifested by decrease of the level of diene conjugates and TBA-reactive products by 27% and 42%, respectively. The patients' antioxidative status increased.

Adrenergic beta-Antagonists↗
PubMed1997

Ferrous-ascorbate complexes as carriers of nitric oxide.

Ferrous-ascorbate is known to form with nitric oxide paramagnetic nitrosyl ferrous-ascorbate complexes, Fe-AA-NO. These complexes yield on EPR signal with g-factor close to 2.02 and an optical absorption spectrum with maxima at 340, 460, and 600 nm. Fe-AA-NO complexes are unstable in the presence of oxygen. Ferrous-ascorbate complexes promote NaNO2 decay resulting in the formation of NO. Nitric oxide is taken up by Fe-AA complexes to form paramagnetic ferrous-ascorbate nitrosyl complexes, Fe-AA-NO. It is suggested that ferrous-ascorbate complexes can play the role of carriers of NO and, perhaps, O2 in the blood plasma. Nitrosyl ferrous-ascorbate complexes can also be the NO containing factor involved in the blood vessel relaxation (endothelium-derived relaxing factor, EDRF).

Ascorbic Acid↗
PubMed1986

[Molecular mechanisms of radiation-sensitizing effects of nitroso compounds: new approaches to the prognosis of their effectiveness].

Basing on the results of EPR investigations and an analysis of literature data an assumption was made of the new factors in the mechanism of the radiosensitizing action of nitro compounds. It was assumed that irradiation-induced accumulation of toxic products of incomplete reduction of the nitro group of these compounds--nitroso- and hydroxyl amino-derivates--in tumor hypoxic zones played the main role in the radiosensitizing action of nitro compounds.

Animals↗
PubMedDate not supplied

[Release of iron ions from transferrin under the effect of nitric oxide].

The dynamics of EPR signals from the iron-transporting blood protein Fe(3+)-transferrine after the administration of sodium nitrite and metronidazole to animals was studied. It was shown that exogenin nitric oxide produced by nitrocompounds resulted in the release of iron from Fe(3+)-transferrine.

Electron Spin Resonance Spectroscopy↗
PubMedDate not supplied

[Interaction of E. coli cells with ascorbic acid and sodium nitrite studied by ESR method].

Ascorbic acid, an effective modulator and regulator of cell metabolism, was shown to induce the production of nitric oxide in E. coli cells. This process was detected by EPR spectroscopy as the generation of a spectral signal typical of nitrosyl-iron-sulfur centers (Fe-S-NO) under anaerobic conditions. Incubation of E. coli cells in the presence of ascorbic acid under aerobic conditions was shown to be accompanied by sodium nitrite formation. It is suggested that ascorbic acid is capable of supporting the system of energy supply to cells in hypoxia caused by reduced oxygen content or treatment with sodium nitrite.

Ascorbic Acid↗
PubMedDate not supplied

[Localization of unpaired electrons in molecules of the substrate inhibitors of lysozyme. II. Oligosaccharides].

It has been shown by the method of electron photosensitized transfer that N-acetyl group is the main electron-acceptor group in oligomeres of N-acetyl glucose amine (AGA). In n-AGA molecules (n-3.5) interacting with an electron radical products of the breakage of glycoside bond are observed, their concentration rising with an increase of the chain length. The ionic strength does not affect the photosensitized transfer of the electron in chitin oligomeres. Formation of paramagnetic centres in the molecule penta-AGA depends on the medium pH.

Acetylglucosamine↗
PubMedDate not supplied

[The EPR spectra of the ribonucleotide reductase in the tumorous tissues and organs of tumor-bearing animals].

Ribonucleotide reductase activity (RRA) has been studied in various tumors and spleens of tumor-bearing animals using EPR technique and biochemical methods. The effect of a number of biologically active compounds on RRA has also been studied. RRA in tumor and spleen increases during tumor growth. Inhibitory effect of irradiation, hydroxyurea, nitrosomethylurea and activatory effect of 5-nitrofurans and nitroimidazole derivatives on RRA has been observed. Regulatory factors of RRA and DNA synthesis in vivo have been discussed.

Animals↗
PubMedDate not supplied

[Role of the electron acceptor properties of lysozyme and its substrate inhibitors in photosensitized electron transport in their complexes by the EPR method].

The nature of electron-acceptor groups in the system of lysozyme with its substrate-inhibitors has been studied in a wide range of pH values by the method of photosensitized electron transfer. In the lysozyme molecule disulphide bonds and peptide groups are the electron--acceptor groups. The nature of radicals in irradiated lysozyme depends on pH. At complex-formation of lysozyme with oligomeres of N-acetylglucosamine the electron transfer from the enzyme molecule to N-acetyl group of the substrate-inhibitor molecule is realized. Under conditions ruling out complex-formation of lysozyme with the inhibitors (N-acetylglucosamine and its dimer) the electrons are localized on disulphide bonds of the protein molecules at alkaline pH and at pH less than or equal to 3 the radicals are observed which are due to the remove of hydrogen atom from the Calpha-atom of the protein polypeptide chain.

Acetylglucosamine↗