Biomedical subjects

Z V Nefedova

Publications and source records attributed to Z V Nefedova.

11 recordsLinked to original sources

PubMed1977

[Patterns of clometacillin circulation in the body of laboratory animals].

Distribution of clometacillin in mice, rats and rabbits was studied in comparison with some other penicillins. It was found that clometacillin was superior to all other penicillins used for comparison with respect to the circulation time in the blood after intravenous, intramusclar or intrastomach administration. As for the capacity for penetrating into the tissues from the blood, clometacillin was not inferior to ampicillin and benzylpenicillin and was superior to propicillin, though it was bound by the blood serum proteins to a greater extent than the other penicillins used for comparison.

Absorption↗

PubMed1977

[Further study of the patterns of penicillin active transport in the kidney tubules of rabbits in vitro and in vivo].

A number of inhibitors of benzylpenicillin active transport in surviving sections of the abbit kidney cortex has been found for the first time. The capacity for such transport was shown with respect to all natural and semisynthetic penicillins tested. The section accumulation method was recommended for the use in screening new penicillins with prolonged action. Absence of corelation between the value of the section/medium concentration gradient and the index of penicillin kidney clearance was registered. It was shown that the binding level of penicillins by blood serum proteins did not define the rate of their excretion with the urine in rabbits.

Animals↗

PubMed1972