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Biomedical subjects

Z Vigváry

Publications and source records attributed to Z Vigváry.

14 recordsLinked to original sources
PubMed1995

[Results of combined multicycle locoregional therapy in the palliative treatment of multiple liver metastases].

Twenty eight patients with multiple liver metastases were treated by locoregional intraarterial chemotherapy including 118 (3-7, mean 4.2) cycles. In the majority of patients the treatments were carried out in the form of combined cytostatic infusions into the hepatic artery using 5-FU, doxorubicin, cisplatin and mitomycin-C and were complemented by transcatheter embolisation, chemoembolisation and lipiodolisation. In some patients the lipiodolisation was choosen as the primary treatment. In patients with metastases from breast cancer (n = 11) 3 CR, 6 PR, 2 MR occured, the mean survival was 18.4 months, while the one- and two-year survival was 7/11 and 4/11, respectively. In the colorectal group (n = 10) 0 CR, 6 PR, 4 MR were achieved with a mean survival of 13.6 months; one-year survival was 5/10. In the third group (n = 7) consisting of also patients with the poorest prognosis a mean survival of 11.5 months (referring to 6/7 patients) could be accomplished. A patient with metastases from a retroperitoneal anaplastic carcinoma is still alive and disease-free for 92 months. Authors emphasise the importance and effectiveness of locoregional treatments in improving the quality of life as well as survival of patients with unresectable liver metastases.

Administration, Topical↗
PubMed1994

[Interventional radiology in pediatrics].

A survey of therapeutic possibilities offered by pediatric interventional radiology is given. Authors emphasize that the percutaneous interventional radiology procedures are performed either as an adjuvant treatment facilitating other (surgical) methods or as definite therapy replacing traditional treatment modalities. It is also stressed that interventional procedures are cost effective and relative less expensive than surgery, and they are not so cumbersome to the patients and can shorten the time for hospitalization significantly. Authors present 5 illustrative cases including locoregional chemotherapy and embolotherapy of liver tumors, transcatheter embolization for a varicocele, an arteriovenous malformation and an aneurysmal bone cyst.

Adolescent↗
PubMed1994

[Treatment methods for malfunctioning endoprostheses].

A survey on treatment options for salvation of malfunctions of biliary endoprostheses is given. If the anatomical situation makes it feasible the endoscopic procedure should be preferred which is less cumbersome to the patient. Percutaneous interventions may include procedures from the mechanical unclogging of the lumen to the removal and changing of the occluded endoprosthesis. The authors emphasize the advantages of the endoprostheses over the external-internal drainage even if interventionalists should count on even multiple changing of endoprostheses due to their tendency to occlusion in patients with a tumor ensuring relative long life expectancy.

Bile Duct Neoplasms↗
PubMed1994

[Oily contrast medium used for chemoembolization in the palliative treatment of extensive inoperable primary hepatocellular carcinomas].

Transcatheter arterial oily chemoembolization using cytostatics mixed with lymphographic contrast agent with or without Gelfoam embolization seems currently to be the most suitable treatment for unresectable hepatocellular carcinomas (HCC). 5 patients with inoperable, biopsy proven huge HCC (average size 404 cm2) were treated by multiple cycles (3-7, average 4.6 cycles) of a triple drug combination including doxorubicin, cisplatin and mitomycin-C together with Lipiodol. In 13/23 cycles the lipiodolization was complemented by Gelfoam embolization increasing the efficacy of treatment. The hypervascular HCC-s showed marked reduction in size (degree of regression was 33-66%, average 55%). The median follow-up was 1918 (13-36 months). Three patients are still alive with follow-up ranging from 15-36 months (average 23 months) despite the progression of the disease. One patient died of tumorous cachexia 13 months after initial treatment, while another one, who developed partial remission, lost his life in a road accident 17 months after his first cycle.

Adult↗
PubMed1992

Neoadjuvant intraarterial chemotherapy of soft tissue sarcomas.

A group of 51 patients with extremity sarcomas of soft-tissue origin received preoperative intraarterial (i.a.) chemotherapy via a percutaneously placed catheter. Treatments were performed as a series of chemotherapy cycles, giving a total of 129, and were carried out in the form of short-term infusions consisting of doxorubicin and cisplatin, which lasted for 20-40 min. These i.a. infusions were combined with complementary methods, such as a tourniquet, occlusion-infusion and chemoembolization. In 3 patients complete remission and in 21 partial remission was registered, while in 27 patients only minimal response could be achieved, although in this latter group necrosis of eight tumors proved to be of significant value. In 43 of 51 patients successful limb salvage surgery was carried out.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1991

[Endoscopic intubation and intracavitary irradiation in the palliative treatment of inoperable esophageal tumors].

The authors have applied at first in Hungary the intracavital after loading radiotherapy in patients suffering from esophageal tumor. A new method was elaborated for the combined use of endoscopic tube insertion and intracavital irradiation. Out of the 155 patients admitted on the 1st Surgical Department of Semmelweis University, Budapest, 63 had been treated only by tube insertion, 44 were intubated and irradiated, whereas 48 patients had intracavital radiotherapy without intubation. Radiotherapy was performed at the Radiological Unit of Semmelweis University. The irradiation dose ranged from 26,9 to 32,2 Gray in average. The mean survival of group I. was 4,0 months, that of group II. 6,3 months, and in group III. 7,0 months respectively. The expected survival is proportional to the radiation dose. No correlation exists between tumor localisation and survival. Respiratory fistula, the most common complication, occurred in different groups as follows: 3,4%, 6,2%, and 9,0%; but could have been treated by tube insertion, or adequate positioning of the tube. The combined use of intubation and intracavital after loading radiotherapy has been proven to be suitable for palliative treatment of inoperable esophageal tumors.

Aged↗
PubMed1991

Advantage of transvaginal over transabdominal sonography.

Results with transvaginal sonography (TVS), a new ultrasound diagnostic method, are reported. A total of 40 patients were comparatively examined by transvaginal and transabdominal sonography. In contrast to transabdominal sonography, the transvaginal examination provided additional information in 35% of the patients. The indications and advantages of transvaginal sonography are summarized as compared with the traditional method. The introduction of the method is recommended in all US laboratories where examinations of the pelvis are performed.

Abdomen↗
PubMed1991

Treatment experiences with intracavitary 137Cs after-loading in a five-year patient material with uterine-cervical carcinoma.

Between 1979 and 1983 a total of 106 patients with carcinoma of the cervix and 53 with that of the uterine body were treated. The irradiation treatment of the patients was carried out by after-loading, with Curietron equipment using 137Cs. Since no reports have so far been published in Hungary on a patient material treated by the above method and with caesium isotope, it seems worthwhile to review the material. Our report is concerned with parameters which enable the assessment of the after-loading method. In cervical carcinoma a five-year survival rate of 59.4% was found, with the same in uterine carcinoma being 69.8%. It should be noted that data referred to all stages in the given tumour. The tumour-free state of the surgical preparations was also examined, and finally, postirradiation complications are also reviewed. Based on our results, the intracavitary Cs137 after-loading is considered by us to be one of the safely and efficiently used procedures in the irradiation treatment of cervical uterine carcinoma.

Brachytherapy↗
PubMed1991

Experience with a new combined method in the differential diagnostics of early endometrial changes.

The authors have performed in 30 cases ultrasonic examination of the endometrium followed by vacuum aspiration with TIS-U-TRAP device (Milex Prod. Inc., Chicago) with equipped a transvaginal head, to obtain samples for histological examination. In 8 of the 30 cases endometrial hyperplasia, while in 2 cases endometrial adenocarcinoma was verified. The authors suggest that transvaginal ultrasonic examination together with vacuum aspiration is suitable for oncological screening of the endometrium.

Adenocarcinoma↗
PubMed1989

[Prospective study of K-cell activity in patients with malignant gynecologic tumors. Effect of radiation therapy].

K cell activity was measured in the enzyme-like kinetic model of cytotoxicity against O, Rh (D) positive erythrocytes in 127 patients with carcinoma of the uterine cervix, 55 with carcinoma of the corpus uteri and 30 with malignant tumors of the ovary. The control groups included 62 healthy age matched women and 39 patients with benign tumor of the ovary. The cytotoxic activity was measured in a number of cases before any treatment and after irradiation and surgery in patients with cervical and endometrial cancer. The target cells were obtained from the same donor. ADCC activity of cervical and ovarian tumor patients enhanced depends on the stage of the disease. K cell activity of endometrial carcinoma patients was similar to the controls. ADCC activity of patients with carcinoma of the uterine cervix was increased, with carcinoma of the uterine corpus was indicated an increasing tendency following irradiation. There was connection with the dose of the irradiation and K cell activity. On the contrary, operation did not influence ADCC activity.

Cytotoxicity, Immunologic↗
PubMed1988

Clinical experience and morphological study on the after-loading treatment of endometrial carcinoma.

According to our experience, the after-loading procedure can successfully be applied in the majority of endometrial cancer cases. Primarily, in those where corpus parameters can be accurately judged and these correspond to the doses to be applied. By devising individual doses, a tumour dose can be planned and administered which in the vesical and rectal wall is amply below the threshold value. (According to our calculations, the posterior wall of the bladder received, on an average, a dose of 5 to 30, while the anterior wall one of 15 to 35 Gy.) The relatively long time of treatment--occasionally 40 to 60 hours--are well tolerated by the patients receiving mild sedatives. The considerable protection of the small intestine is due to the protracted method of a low R/min. The lack of complications in the small intestine can be attributed to this fact. Beside all these results, application, localization and nursing can be made in a radiation-free environment. For examining the effectivity of after-loading treatment, light- and electron microscopic studies were performed in patients with endometrial carcinoma (in 6 and 8 cases, respectively) to support also morphologically the favourable results of clinical practice.

Adenocarcinoma↗
PubMed1986

Peridural morphine analgesia by means of a subcutaneously tunnelled cannula.

Peridural morphine analgesia is a well tested method of pain relief for patients with gynecological tumors which are in an advanced stage. Traditional methods of fixation can slightly inconvenience the patient when cleaning and dressing procedures are being carried out, and the cannula can be displaced or damaged. Fifty patients were treated with subcutaneously tunnelled peridural cannula. The procedure and its favorable results are described.

Administration, Cutaneous↗