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Z Vitková

Publications and source records attributed to Z Vitková.

25 records · Page 2Linked to original sources
PubMedDate not supplied

A study of local anaesthetics. Part 148. Influence of auxiliary substances on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII.

The influence of auxiliary substances of the polyol group (glycerol, propylene glycol, sorbitol) and of their concentration (5, 10, 15 and 20% by weight) upon surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII, viz., N-[2-(2-propoxyphenylcarbamoyloxy)-ethyl] piperidinium chloride was studied. The substances were applied as hydrogel humectants. It was found that their influence on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII depended on the type as well as concentration of the auxiliary substance. From the viewpoints of use in formulations of the drug form, sorbitol used at 5 and 10% concentrations represented the optimum.

Anesthetics, Local↗
PubMedDate not supplied

Influence of hydrogel bases on liberation rate and structural viscosity of potential drug XX Z.

Influences of cellulose derivatives (with and without additives of humectants) on two parameters, namely the liberation of the potential local anaesthetic XX Z and the structural viscosity of preparations were compared. The aim was to select a suitable base for topic application of the substance XX Z, chemically pyrrolidinoethylester of 3-heptyloxyphenylcarbamic acid. The rate of release of the substance XX Z from 2.5% methylcellulose base was higher then from 2% hydroxyethylcellulose base, and in both cases it was reduced after addition of humectants. It is concluded that among bases with additives of humectants is, for topic applications, more suitable the hydroxyethylcellulose base then methylcellulose base.

Anesthetics, Local↗
PubMedDate not supplied

The influence of glycerol, propylene glycol and sorbitol on surface tension, partition coefficient and diffusion of pyrrolidinoethylester of 3-heptyloxy phenylcarbamic acid (drug XX Z).

The influence of glycerol, propylene glycol and sorbitol on surface tension, partition coefficient and diffusion of pyrrolidinoethylester of 3-heptyloxy phenylcarbamic acid (Drug XX Z) from solutions has been studied. It was found that each of the three mentioned auxiliary substances causes, proportionally to its concentration (5, 10, 15 and 20%), the increase of the surface tension and the decrease of the partition coefficient. A correlation between the surface tension and partition coefficient was proved. The diffusion of the drug XX Z was increased due to use of the auxiliary substances. With respect to these results and in accordance with the rules for development of the drug form, sorbitol in concentration 5-10% seems to be an optimal auxiliary substance.

Anesthetics, Local↗
PubMedDate not supplied

Study of local anaesthetics. Part 136. Influence of auxiliary substances on the release of pentacaine from drug forms.

The paper deals with the formulation of a potential local anaesthetic--pentacaine into appropriate drug forms. To be more specific, the pentacaine is studies from the two aspects. First, the influence of auxiliary substances and their respective concentrations on the both onset and duration of local anaesthetic effects of pentacaine solutions. Second, the liberation of pentacaine from hydrogels and suppositories. Based on the obtained results, optimal auxiliary substances together with their optimal concentration are recommended.

Anesthesia↗