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Biomedical subjects

Z W Guo

Publications and source records attributed to Z W Guo.

12 recordsLinked to original sources
PubMed1999

Esophageal reconstruction by jejunal transfer.

Forty-five esophageal reconstructions were carried out using a free or pedicled transfer of jejunal segments. Thirty were performed for benign stenosis or atresia, and 13 were performed for malignancy. The remaining two were used to repair anastomotic leakage or fistulization resulting from prior esophagogastrostomy. Average anastomotic arterial and venous diameters were 1.2 mm and 3.0 mm respectively. Of the 45 reconstructions, 44 were successful; the single failure was the result of tearing of the mesenteric arcade. There were four fatalities. Jejunal transfer is an effective method of esophageal reconstruction.

Adolescent↗
PubMed1998

Synthetic study on a novel Asn-linked core structure: synthesis of a pentasaccharide alpha-D-Man-(1-->3)-[alpha-D-Man-(1-->6)]-beta-D-Man-(1-->4)- [beta-D-GlcNAc-(1-->60]-beta-D-GlcNAc-->OMp.

Synthesis of a pentasaccharide alpha-D-Man-(1-->3)-[alpha-D-Man-(1-->6)] -beta-D-Man-(1-->4)-beta-D-GlcNac(1-->6)]beta-GlcNAc-->Omp (2) is described. A comparison between the 1H NMR data of 2 and those of a novel Asn-linked core structure 1 containing a new GlcNAc residue suggests an alpha-D-configuration for the new linkage.

Acetylglucosamine↗
PubMed1997

Solid-phase synthesis of CD52 glycopeptide and an efficient route to Asn-core pentasaccharide conjugate.

The intact peptide sequence (18) as well as its glycoform carrying an N-linked core pentasaccharide (1) of CD52 antigen were prepared by means of solid-phase synthesis employing Fmoc-amino acids and benzyl-protected oligosaccharide-asparagine conjugate (3) as building blocks. It was concluded that the pentasaccharide structure had little influence on further peptide elongation in solid-phase synthesis and the benzylated pentasaccharide moiety was sufficiently stable to the 95% TFA acidic conditions used to release glycopeptide from the supporting resin. The paper also describes an efficient route leading to asparagine-core pentasaccharide conjugate (3) which was prepared in seven steps for an overall yield of 23% from monosaccharide units 5, 6, 7 and 8.

Antigens, CD↗
PubMed1997

[The effect of chaihu qingxin yin on left cardiac function and T-cell subgroup in peripheral blood in children with viral myocarditis].

OBJECTIVE: To observe the effect of Caihu Qingxin Yin (CHQXY) in treating viral myocarditis. METHODS: CHQXY was used to treat 52 cases of acute viral myocarditis in children, compared with the routine method using energy mixture in 32 patients. RESULTS: (1) The total effective rate of 52 patients using CHQXY was 71.2% which was higher than that of the control group in 32 patients with 53.1%, Ridit analysis, P < 0.01. (2) Functional shortaxial shortening rate (FS) and ejecting fraction (EF) in CHQXY group were superior to those of the control group, P < 0.01. (3) CHQXY might modulate the immune function of T lymphocyte, enabled the CD3 and ratio of CD4/CD8 tended to normalize. CONCLUSION: CHQXY played an important role in the treatment of viral myocarditis with the mechanism of improving the left cardiac function and modulating celluar immune function.

Adolescent↗
PubMed1996

[Clinical and experimental studies on zhikang oral liquid in treatment of hypophrenia].

The effect of Zhikang Oral Liquid (ZK) on 50 cases of hypophrenia children was observed and a control group of 20 cases was set. Results showed that the total effective rate of ZK group was 82%, it was significantly higher than that of control group (P < 0.01). Animal experiment revealed that ZK could improve the hypomnesia in learning caused by anisodine, poor memory retention caused by sodium nitrite and memory hypo-reproducibility caused by 40% alcohol. The results of clinical and experimental studies suggested that ZK could promote the intelligence development of child and improve the memory.

Adolescent↗
PubMed1994

[Effect of Chinese herbal preparation on major constituents of bile of gallstones patients].

From 1991 to 1993, 51 patients in 3 groups who had received biliary operation with T tube drainage were selected for observation of dynamic change in bile acid, bilirubin, cholesterol and mucin in the bile within 3 days after taking the Danyihewei granule (DYHW) and Rongshisan (RSS). Result showed that in DYHW group the bile acid increased significantly on the 2nd and 3rd day (P < 0.01), along with significant lowering of bilirubin (P < 0.01) and mucin (P < 0.05, P < 0.01) in 1st through 3rd day. In the RSS group the bile acid remarkably increased on the 3rd day (P < 0.05) with significant reduction of bilirubin (P < 0.01) on 2nd and 3rd day. The control group showed no remarkable change. The bile acid/bilirubin and bile acid/cholesterol ratios all had a dynamic increase with 3 days in treated group. Whereas the control group remained unchanged. Therefore the DYHW and RSS were able to produce a strong inhibitory effect on stone-forming bile through regulation of liver and discharge of bile.

Adolescent↗
PubMed1990

[Studies of synthesis and structure-activity relationships of analogs of the muscle relaxant--baclofen].

In an effort to study the structure-activity relationship of analogs of baclofen and to search for more potent and less toxic muscle relaxants and analgesics, fifteen 3-substituted pheny-4-aminobutyric acids and their derivatives were synthesized. Preliminary pharmacological tests in albino mice showed that some of the target compounds exhibited muscle relaxant and analgesic effects. Compounds Ib, IIb, IIIa, IIIc and compounds Ib, IIb, IIIa, IIIb were, respectively, more potent in hot plate tests and morphine-induced straub tail reaction tests than other analogs, but they were still less potent than baclofen. The structure-activity relationship showed that the effects of baclofen were strongly structure specific, and the results also suggested that at least three groups in baclofen-phenyl, amino and carboxy--take important parts in the combination of baclofen with GABAB receptor.

Animals↗