PubMed Health⌕ Search

Biomedical subjects

Z W Yu

Publications and source records attributed to Z W Yu.

26 records · Page 2Linked to original sources
PubMed1994

Dimethyl sulphoxide: a review of its applications in cell biology.

Dimethyl sulphoxide is a water miscible solvent that has wide applications in cell biology. It acts as a cryoprotective agent in a variety of cells and tissues allowing prolonged storage at subzero temperatures. The action of dimethyl sulphoxide on the stability of the liquid matrix of cell membranes appears to be responsible for its effects and this appears also to be true for related effects on membrane permeability and fusion. Dimethyl sulphoxide is also known to act as an inducer of cellular differentiation and as a free radical scavenger and radioprotectant. A review of the underlying molecular basis of all these effects of dimethyl sulphoxide is presented.

Animals↗
PubMed1989

[Diagnostic significance of the determination of serum alpha-L-fucosidase in primary hepatocellular carcinoma].

The results of determination of serum alpha-L-fucosidase (AFU) in healthy individuals, in patients with various liver diseases and non-liver malignant diseases were reported. In primary hepatic carcinoma the level of serum AFU was significantly higher than that in various other diseases and healthy persons (P less than 0.001). The serum AFU level was independent of AFP level (x = 1.24, P greater than 0.25). These data suggest that AFU may be a useful marker for the diagnosis of primary hepato cellular carcinoam with negative AFP.

Biomarkers, Tumor↗
PubMed1987

[Clinical study of subclinical hepatic cancer--analysis of 187 patients].

187 patients with subclinical hepatic cancer (SHC), collected by mass screening or follow-up of the hepatic diseases in our hospital from Dec. 1972 to Dec. 1984, are reported. The age ranged from 18 to 76 years with a median of 47. The sex ratio of male and female was 1.97:1. 143 (76.5%) patients had a positive pathology. The exploration rate was 60.4% and resection rate was 77.9%. Of them, there were 72 (81.8%) small liver cancers with lesions equal to or less than 5 cm in diameter. For patients with resection, the 1, 3 and 5 year survival rates were 77.3%, 39.3% and 34.6%, markedly higher than those treated by other means. B-ultrasonography gave a significantly higher positive rate (96.4%) in the localization of SHC, compared with nuclide imaging (17.6%). Basing on analysis of 187 patients with SHC, close follow-up of the subjects with low level persistent positive alpha-fetoprotein without active liver disease plays an important role in the early detection of SHC.

Adolescent↗
PubMedDate not supplied

The modulation of membrane structure and stability by dimethyl sulphoxide (review).

Dimethyl sulphoxide is a widely used agent in cell biology. It is well known as a cryoprotectant, cell fusogen and a permeability enhancing agent. These applications depend, to a greater or lesser extent, on the effect of dimethyl sulphoxide on the stability and dynamics of biomembranes. The aim of this review is to examine progress of the research which has been directed towards studies of the interactions between dimethyl sulphoxide and membranes, particularly that with the lipid components of cell membranes, as seen in its effects on model membrane systems. Models are proposed to explain the mechanism whereby dimethyl sulphoxide may mediate its effects on biological functions by its effects on the stability and properties of the membrane lipid matrix.

Animals↗