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Biomedical subjects

Z Wasek

Publications and source records attributed to Z Wasek.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Three month treatment with budesonide in patients with corticoid dependent bronchial asthma--personal experience].

The experiment aimed at evaluating a three-month therapy of asthmatic patients with budesonide inhalations. The study involved 32 patients with long-lasting bronchial asthma depended on steroids. Therapy with budesonide (Pulmicort Astra) in a mean daily dose 1.6 mg enabled withdrawal of depot steroids and inhalation treatment only. In patients receiving prednisone in a mean daily dose 5.0 +/- 4.8 mg, budesonide therapy enabled a reduction of the oral dose by 50 percent. A significant improvement in the psychophysical status of patients has been noted despite a lack of significant differences in the results of lung functioning tests. Adverse reactions such as relaxation, insufficiency of the vocal cords at phonation and hoarseness were seen in 20 percent of patients, and in one of them required cessation of the drug. An increase in the number of Candida albicans colonies in throat swabs (over 20 colonies per plate) was seen in 7 treated patients but clinical symptoms which required an additional treatment were noted only in 1 patient.

Adult↗
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[Incidence of antigen expression for HLA antigens A,B,C and DR in patients with atopic diseases in Poland].

Studies of several authors suggest an interdependence of atopic diseases and HLA antigens. Therefore, the authors evaluated an incidence of HLA antigens of classes I and II in patients with atopic disease and healthy individuals. The study involved 127 patients with atopy and 79 healthy blood donors. Anamnesis, results of skin tests and serum levels of allergenic-specific IgE served as the base of atopy diagnosis or exclusion. HLA antigens were assayed with a standard micro-lymphocytotoxic test using two series of standard anti-HLA sera. It enabled to detect 16 locus A-dependent antigens, 25 locus B-dependent and 8 locus C-dependent antigens as well as 8 antigens dependent on locus DR. Only antigen HLA-Bw53 was found more frequently in patients with atopic diseases suggesting its relation to atopy. The results concerning other HLA antigens did not confirm HLA antigens association with atopy suggested by other authors.

HLA Antigens↗