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Biomedical subjects

Z X Zhu

Publications and source records attributed to Z X Zhu.

At least 19 recordsLinked to original sources
PubMed1999

Experience of urgent reconstruction of electrical injuries.

Although there have been great advances in the treatment of electrical injuries in the last 20 years, the extremity loss ratio in electrical injuries remains at an unacceptably high level. The primary reason for this is the progressive tissue necrosis and enlargement of the necrosis in the wound. The goal in this study is to examine possible ways to break the necrotic malignancy circle and save the form and function of damaged extremities. As a result of systematic experimental and clinical research, a comprehensive urgent reconstruction alternative for electrical injuries has been proposed. The alternative includes the following principles: debriding the wound as early as possible after injury; preserving as much as possible the vital tissue structures, such as nerve, vessels, joints, tendons, and bone, even when they have undergone devitalization or local necrosis; transplanting these vital tissues during the first surgery if the functional reconstruction requires; nourishing the wound bed by covering with tissue flaps that have rich blood supply; improving flap survival by continuous irrigations with a compound medicine beneath the flaps for a 24- to 72-hour period after surgery; providing general treatment with vasoactive agents and antibiotics. This paper summarizes our experience of using this method in the treatment of 105 electrical injury patients (a total of 309 wounds) in the time period from 1 January 1986 to 31 December 1996. Satisfying results were obtained, with the extremity loss ratio decreasing to 7% as compared to 41.5% during the 10 years preceding 1984 at the same hospital. Thus, the urgent comprehensive reconstruction alternative presented here is an effective and workable method to manage electrical injuries.

Adolescent↗
PubMed1996

Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats.

AIM: To determine whether argipressin (Arg) plays a role in central neural control of cardiovascular function by acting on the lateral septal nuclei (LSN). METHODS: Measuring mean arterial blood pressure (MAP) and heart rate (HR) responses followed microinjection of Arg into the LSN of rats anesthetized with urethane. RESULTS: Arg (100, 200, and 400 ng) injected into the LSN produced a dose-dependent hypertension and tachycardia. Maximal changes of MAP were 0.9 +/- 0.6, 2.3 +/- 1.3, 4.0 +/- 1.4 kPa, respectively; maximal changes of HR were 12 +/- 27, 50 +/- 33, and 89 +/- 27 bpm, respectively. Pretreatment of the LSN with a vasopressin 1 type antagonist d (CH2)5Tyr(Me) Arg abolished the MAP and HR responses produced by injection of Arg. Peripheral alpha-adrenergic blockade with phentolamine blocked the hypertension responses to injection of Arg into the LSN. CONCLUSION: Arg acts in the region of the LSN to exert a central action on the cardiovascular system that is mediates by stimulation of sympathetic outflow.

Animals↗
PubMed1993

Successful treatment of a severe electrical injury involving the stomach.

Apparently no report of the survival of a child with severe electrical injuries involving the stomach has been published. We successfully treated a 5-year-old boy with such injuries in August 1991. Our effective treatment included: (1) resection of the necrosis of the stomach immediately after admission; (2) active excision of all surrounding necrotic tissues with conservation of any piece of healthy tissue, including partial degenerative tissues; (3) early coverage of all exposed areas; (4) general comprehensive supportive therapy, and (5) local application of a saline solution containing chloromycetin and lidocaine.

Burns, Electric↗
PubMed1993

[Injury score for deep burns--(1) Structure and functions of extremity].

The investigation of the structure, functions and functional loss ratio of the burn injuries was carried out in twelve cross sections of the extremities in this paper. The basic structure-function constants of the vessel, nerve, tendon, muscle, bone joint capsule and ligament were obtained from the investigation and converted into index. We hope that the index would provide a reliable numerical indication system for the early diagnosis and repair of the deep burn injuries.

Burns↗
PubMed1993

[Index for deep burn injuries: (2). Analysis of 117 cases].

A trial to index for deep burn injuries (IDBI) on the basis of 304 burn sites in 117 patients was reported in this paper. Based on the index, a gradation of IDBI from Type I to Type V was developed. Further analysis of the 117 cases suggested that the IDBI might provide a reliable numerical indication system for the early diagnosis, guide for repair, prognosis as well as further study in the field of the deep burn injuries.

Adolescent↗
PubMed1993

[Early repair of burned cranium].

Early repair was done on 10 patients, of whom there was necrosis of either the outer or both outer and inner tables of the skull as a result of deep burn injuries. Multiple drill holes were made through the necrotic cranial bones until bleeding occurred on 7 PBD. The wounds were immediately covered with skin flaps. A continuous drip of lidocaine, chloramphenicol and normal saline was instituted underneath the flaps. The results after one to five years follow-up were satisfactory.

Adolescent↗
PubMed1991

Identification of basement membrane zone antigens defined by antibodies that react to both the epidermal and dermal side of 1 M sodium chloride split skin.

Some individuals have basement membrane zone (BMZ) antibodies that react to both the epidermal and dermal side of skin split with 1 M NaCl. To examine the significance of this combined staining pattern, we tested sera from 185 different, sequential, patients with BMZ antibodies for reactivity to normal human skin split with 1 M NaCl. Six sera (3.2%) stained both the epidermal and dermal sides of split skin, 173 (93.5%) stained only the epidermal side, and 6 (3.2%) only the dermal side. All six sera with a combined staining pattern yielded the same pattern when tested with three different specimens of skin, indicating that this pattern is reproducible. By immunoblot analysis, five (83%) of the six combined staining sera reacted to a 160-kD antigen present only in epidermal extracts of normal skin, one reacted in addition to a 230-kD epidermal antigen, and one did not react to either epidermal or dermal extracts. In contrast, five (83%) of the six sera with dermal staining reacted to a 290-kD antigen present only in dermal extracts. Eighteen (90%) of twenty representative epidermal staining sera reacted to a 230-kD epidermal antigen and seven (35%) sera (five with the 230-kD antibody and two without) also reacted to the 160-kD epidermal antigen. Affinity purified antibody to the 160-kD antigen defined by combined staining sera reacted to the BMZ of normal human skin. These results indicate that the combined staining pattern on 1 M NaCl split skin is due to the presence of a distinctive antibody response directed predominantly to a 160-kD BMZ antigen located on the epidermal side of the split skin and to an as yet unidentified BMZ antigen located on the dermal side.

Aged↗
PubMed1991

[Experimental electric injuries: repair and histology].

66 rats were submitted to bilateral hindlimb high-voltage electric injuries. When palliative debridement, followed by flap transplantation, was done within 48 hours after the injury, both the external appearance and functions were restored satisfactorily. On the contrary, when radical debridement or skin grafting with split thickness skin was done, all the limbs lost their functions. The results suggest that early palliative debridement and good coverage with skin flap are feasible in the treatment of electric burns.

Animals↗
PubMed1990

Maximum acceptable repetitive lifting workload by Chinese subjects.

This study used psychophysical methods to determine the acceptable mean maximum lifting workload for eight Chinese young male subjects, and examined the effects of lifting technique (including freestyle, stoop and squat), lifting frequency (including 2, 3, 4, 5 and 6 lifts/min) and physical characteristics on the maximum acceptable workload. The results are described as follows: (1) The maximum acceptable weights selected by subjects varied from 11.34 to 18.33 kg with changes in lifting technique and frequency. These data were lower than those previously obtained; (2) The upper limit of physiological tolerance over an 8 h workday was also generally lower than previously suggested. However, this upper limit varied with changes in lifting technique and frequency, and in some circumstances it was the same as or even higher than previous limit; (3) Lifting efficiency was affected significantly by technique and frequency. The rank order of efficiency for three lifting techniques were freestyle, stoop and squat. Efficiency was greatest when lifting frequency was between 5 and 6 lifts/min; and (4) The correlations between the maximum acceptable workloads selected by subjects and anthropometric sizes were significant, but those between maximum acceptable workload and isometric strength were not.

Adult↗
PubMed1990

Repair of experimental high voltage electrical injuries.

Repair methods for high voltage electrical injury were studied in 46 rats submitted to symmetrical bilateral hind limb electrical injuries using 1,600 V AC. Out of 40 hind limbs of the 40 rats which were treated with conservative debridement and flap coverage, 20 limbs repaired prior to the 48th post-injury hour obtained a good appearance and functions, the rest operated after the 4th post-injury day showed partial or complete disability. Forty contralateral limbs served as controls, including 20 hind limbs grafted with mesh-grafts which recently necrotized and 20 of them debrided thoroughly resulting in substantial loss of tissue, showed disabling effects. The investigation suggested that a better appearance and functions in such injuries would be obtained if using the technique of immediate conservative debridement and flap coverage.

Animals↗
PubMed1990

Urgent repair of electrical injuries: analysis of 40 cases.

40 patients suffering from electrical injuries were rehabilitated using a new system of urgent conservative debridement and flap coverage in the period from October 1984 to July 1988. For this purpose, a 1-4 year follow-up was needed. Good appearance and functions of the extremities or organs were obtained and the amputation rate was lower (7.5%) than that used in patients treated with traditionally conservative methods (47.7% in the same hospital.

Adolescent↗
PubMed1990

[Early repair of deep burns of the foot].

Early repair of 11 feet of 10 burned patients over four-year period was presented. The injured or necrosed vessel, tendon, nerve and bone joint were retained during debridement and covered with different kind of flaps including free flap. The good appearances and functions were obtained in 9 feet, one ankle joint showed slightly disability and five digits of the rest feet were amputated. The characteristics of the burned foot was also discussed in this paper.

Adolescent↗
PubMed1990

[Detection of circulating antigen and/or antigen-antibody complex by using McAb against surface membrane antigen of adult Schistosoma japonicum].

In the present paper, the results of detecting circulating antigen and/or antigen-antibody complexes by McAb against surface membrane antigen of adult Schistosoma japonicum were reported. The McAb, coded as 8SE4, was prepared by fusion of SP2/0 myeloma cells with spleen cells of the BALB/c mice immunized with the saline extract of adult S. japonicum. The 8SE4- directed antigen was proved to be located on the surface of the adult worm. After being purified by a DE52 column, 8SE4 was labelled with HRP and the conjugate (HRP-8SE4) was used in the test. For testing, the serum sample was first incubated with HRP-8SE4, then PEG (mw. 6,000) was added to precipitate the antigen-antibody complex. Upon centrifugation, OPD was added to the precipitate. Results were read by ELISA reader at 492nm. The OD value was found to be proportional to the amount of circulating antigen and/or antigen-antibody complexes. Results from 5 heavily infected (1,500-2,000 cercariae) rabbits showed that the OD values were raised significantly at the 6th week post infection, being 1.9-4.5 times higher than those before infection. The OD values of the 5 rabbits each lightly infected with 10-500 cercariae were also markedly raised 6 weeks post infection and reached the peak at the 8th week, then maintained in high levels until 11th week post infection. The worm burden of the 5 lightly infected rabbits were 4-326. No obvious correlations between OD values and worm loads were observed. The results suggested the existence of surface membrane-related antigen and/or antigen-antibody complexes in the circulation of infected rabbits.

Animals↗
PubMed1990

Increasing flap survival: a new method.

A new method of continuous irrigation beneath a flap with special irrigation was designed to attempt to improve flap survival in 42 animals. In each animal experimental and control flaps were symmetrically designed using two flanks or limbs (total number of flaps, 154). The flap length survival in the 77 experimental flaps ranged from 18 to 88% greater than that in the control flaps. Bacterial cultures of the secretions from all flaps suggested that this method has a practical value in preventing and controlling the infections that would result in flap necrosis.

Animals↗
PubMed1989

Reduction of enteric infectious disease in rural China by providing deep-well tap water.

Enteric infectious disease (EID), defined here as bacillary dysentery, viral hepatitis A, El Tor cholera, or acute watery diarrhoea, is an important public health problem in most developing countries. This study assessed the impact on EID of providing deep-well tap water (DWTW) through household taps in rural China. For this purpose, we compared the incidence of EID in six study villages (population, 10,290) in Qidong County that had DWTW with that in six control villages (population 9397) that had only surface water. Both the bacterial counts and chemical properties of the DWTW met established hygiene standards for drinking water. The incidence of EID in the study region was 38.6% lower than in the control region; however, the introduction of DWTW supplies did not significantly affect the incidence of bacillary dysentery. These results indicate that the construction and use of DWTW systems with household taps is associated with decreased incidences of El Tor cholera, viral hepatitis A, and acute watery diarrhoea. Since high construction costs have led many authorities to question the value of DWTW, we carried out a cost-benefit analysis of the programme. The cost of constructing a DWTW system averaged US $36,000 at 1983 prices, or US $10.50 per capita. The combined capital and operating costs of a DWTW system were US $1.46 per capita per annum over its 20-year estimated life. The benefits derived from reductions in cost of illness and savings in time to fetch water were 2.2 times the costs at present values Capital outlays were recouped in a 3.6-year payback period and the provision of DWTW proved highly beneficial in both economic and social terms.

Adolescent↗
PubMed1989

[Observation of oral glucose-insulin releasing test in liver cirrhosis].

In order to investigate the disorders of carbohydrate metabolism and insulin secretion as well as their correlation in patients with liver cirrhosis, we performed an oral glucose tolerance test on 30 patients with liver cirrhosis proven by history, clinical findings, liver function test, radioisotope liver scanning, ultrasonic examination, gastroscopy, barium esophagogram and liver biopsy, compared with 20 healthy controls. Blood glucose and immunoreactive insulin were determined in both groups at 60 min intervals for 180 min. Results showed marked glucose intolerance with peak value 60 min after glucose load in cirrhotic patients with normal fasting blood glucose. Plasma IRI levels were significantly higher in cirrhotic patients than in normal subjects after glucose load (P less than 0.05), especially 180 min after (P less than 0.01). Twelve of 30 cases (40%) showed an abnormal OGTT curve. Of the 12 cases seven (23.3%) showed a diabetic OGTT curve, five (16.7%) an impaired OGTT curve. While eighteen of 30 cases (60%) showed an abnormal OGIRT curve. Among the 18 cases one (3.3%) presented hypersecretic OGIRT curve, twelve (40.0%) with delayed and prolonged peak, and five (16.7%) with hypersecretic OGIRT curve and delayed, prolonged peak.

Adult↗
PubMed1989

[Immunological humoral response in mice experimentally infected with Echinococcus granulosus, preliminary result of kinetic observation].

5 serological methods included latex agglutination test (LA), enzyme-linked immunoelectrotransfer blot (EITB), enzyme-linked immunosorbent assay (ELISA), dot-enzyme-linked immunosorbent assay (Dot-ELISA) and immunofluorescence antibody test (IFA) were used to trace the kinetic changes of the humoral response in NIH mice experimentally infected with protoscolex of Echinococcus granulosus. Results showed that Dot-ELISA and IFA were able to detect antibodies 2 wk after infection while ELISA, EITB and LA gave positive reactions 4 wk, 2 mos and 3 mos after infection respectively. Therefore Dot-ELISA and IFA were considered to be the most sensitive ones among the 5 methods used. All infected mice gave positive reactions at 8 and 12 mos but none of the normal control mice showed any reaction throughout the period of observation (Fig. 1).

Animals↗