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Z Y Qin

Publications and source records attributed to Z Y Qin.

14 recordsLinked to original sources
PubMed1997

[Effects of basic fibroblast growth factor on anoxia/reoxygenation injury of rat neonatal cardiomyocytes].

The effects of basic fibroblast growth factor (bFGF) on anoxia/reoxygenation (A/R) injury and protein kinase C (PKC) activity were studied on a model of A/R injury of neonatal rat cardiomyocytes to investigate the possibility of its using as a substrate for pharmacological preconditioning. The data indicated that bFGF improved the viability of cardiomyocytes, lowered the deplection of ATP and leakage of intracellular lactate dehydrogenase (LDH) in a concentration-dependent manner. PKC inhibitor, H7, completely abolished the protective effects. It was also found that bFGF directely activated PKC in cardiomyocytes in a time course similar to that in hypoxic preconditioning. The data suggested that the protective effect of bFGF on cardiomyocyte A/R injury might be mediated by PKC.

Animals↗
PubMed1989

An experimental study by single blind method on the anti-obesity effect of Xiaopangmei.

To evaluate the anti-obesity effect of Xiaopangmei, an experimental study by single method in three groups of rats was done. The first group were fed with Xiaopangmei-01, the second group with a placebo, and the third group were controls. As compared with the control and the placebo groups, the rats that had been fed Xiaopangmei for six weeks showed body weight, food intake, weight of epididymis fat pad and the intestinal absorption of glucose all significantly decreased. The swimming tolerance test showed they swam longer than the other two groups. No significant difference was found between the three groups in the growth and development indices such as body length, length of femur and tibia, weight of heart, lungs, spleen, kidneys, stomach, small intestines, gastrocnemius muscle, and adrenal glands. No side effects were found on the liver and kidney. The secretion of insulin was inhibited after the swimming tolerance test and the gastrocnemius muscle test was similar for all three groups of rats. We concluded that Xiaopangmei is an effective anti-obesity drug.

Animals↗