[Melatonin in seasonal affective disorder].
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Biomedical subjects
Publications and source records attributed to Z Y Xia.
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The authors found that 73 (8.4%) of 866 patients with chronic schizophrenia in the Shanghai Psychiatric Hospital who had been treated with neuroleptics had tardive dyskinesia. This low prevalence rate is possibly ascribable to the use of relatively low doses of neuroleptics.
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Using a highly specific and sensitive radioimmunoassay for dynorphin(1-8) (D 1-8), and a singly blind test design, we measured D(1-8) immunoreactivity (ir D 1-8) in CSF of 35 first break cases of acute schizophrenic patients. All patients were free of psychotropic medication for at least one week before the study. Another 31 neurological patients suffered from cervical arthrosis, tumor, myelopathy etc. were studied as controls. The ir D(1-8) in CSF of schizophrenic patients were significantly lower than that of controls (91.8 +/- 5.6, means +/- S.E.M., and 131.9 +/- 6.8 fmol/ml CSF respectively, p less than 0.001).
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