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Z Z Kirtava

Publications and source records attributed to Z Z Kirtava.

9 recordsLinked to original sources
PubMed1989

Subjective disease experience in Sjögren's syndrome. A computerized discrimination analysis.

A study was made of the ability of a computerized discrimination analysis to distinguish between primary or secondary Sjögren's syndrome on the one hand and, on the other, various rheumatic diseases which may be, but in this study were not, complicated by Sjögren's syndrome. The analysis was based on a questionnaire including 76 two- or three-scale items. Among these 76 questions, five with a maximum potential for distinguishing between various subgroups were selected and obviously represent the questions for the physician to ask when taking the patient's history. As shown by classification matrix tables, computerized analysis of questionnaires might represent a useful way to assess the prevalence of clinical cases of Sjögren's syndrome and to aid health care administrators in assessing the extent of the Sjögren's syndrome problem. In contrast, manual analysis of patients' graded answers did not provide any simple or practicable method for the diagnostic work-up of cases. Therefore it seems that subjective symptoms should not be included in the diagnostic criteria for Sjögren's syndrome, which in clinical work should be based on objective evidence alone.

Arthritis, Rheumatoid↗
PubMed1988

[Sjögren's syndrome in systemic scleroderma].

Combined investigation of 43 patients with sclerodermia systematica (SSD) was conducted to detect Sjogren's syndrome (SS) and to study SSD association with SS. Four groups of patients were defined: with marked SS (10), primary SS (12), probable SS (13), and without SS manifestations (8). Comparative characterization has shown that SS is detected slightly more frequently in a chronic course of SSD, combines with manifestations of sclerodactyly, telangiectasia, calcinosis, however esophageal hypomobility, indurative skin changes and contractures which are typical of SSD, occur less frequently than in SSD patients without SS. SSD association with SS is characterized by polyarthralgia, arthritis, marked Raynaud's syndrome, the frequency and rather high RF titers, the detection of anti-Ro and anti-La, and a significant rise of the level of circulating immune complexes determined by SS influence. SS manifestations in SSD are retention pains in the parotid glands, signs of clearness on sialograms, periductal sclerosis in the form of rings in morphological investigation of the parotid glands.

Adult↗
PubMed1987

[A positive effect of combined therapy (plasmapheresis in combination with pulse therapy) on the course of cryoglobulinemic glomerulonephritis and ulcerative-necrotic vasculitis in patients with Sjögren's disease].

The authors provided evidence of a positive effect of combined therapy (plasmapheresis in combination with pulse-therapy) on a course of cryoglobulinemic glomerulonephritis and ulcerative-necrotic vasculitis in patients with Sjögren's disease (SD). It was shown that plasmapheresis with double plasma filtration considerably decreased the cryoglobulin level in the blood whereas the level of alpha 2-globulins, C-P, RF and CIC did not change 16 hrs after the sessions of plasmapheresis. These indices significantly decreased after pulse-therapy with high doses of 6-methylprednisolone and cyclophosphamide following plasmapheresis. Combined therapy resulted in a complete epithelization of leg ulcers, regression of the symptoms of renal failure. Clinical improvement correlated with a decrease in indices of the inflammatory and immunological activity and with an increase in the cutaneous blood flow. Combined therapy can be an effective therapeutic method of SD complicated by cryoglobulinemic glomerulonephritis and ulcerative-necrotic vasculitis.

Acute Kidney Injury↗
PubMed1986

[Antinuclear antibodies in Sjögren's disease and syndrome].

A study was made of the presence of antinuclear antibodies to Ro, La, nDNA, RNP and Sm in 18 patients with Sjögren's disease (SD) and in 13 patients with Sjögren's syndrome (SS). Anti-Ro and/or anti-La were revealed in 12 SD patients (67%) and in 3 SS patients (23%, P less than 0.05) only. Anti-nDNA and anti-RNP were detected in 39 and 15% of the SS patients respectively and were undetectable in the SD patients. Anti-Ro and/or anti-La were detected in all SD patients, III degree activity, and associated with the presence of Raynaud's syndrome, recurring nonerosive arthritis and the absence of adequate therapy. Anti-Ro only were detected in 44% of the SD patients only and in none of the SS patients. Higher values of ESR, RF and CIC were revealed in the SD patients with anti-La and especially anti-Ro.

Adolescent↗
PubMedDate not supplied

[The clinical significance of disorders of humoral immunity in Sjögren's disease and syndrome].

Data on 100 patients: 50 with Sjögren's disease (SD) and 50 with Sjögren's syndrome (SS) accompanied by systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic scleroderma (SSD) were analysed. It was characteristic of SD to have hyperproteinemia, hypergammaglobulinemia, high levels of the rheumatoid factor (RF), circulating immune complexes (CIC), and cryoglobulins, anti-Ro and anti-La; SD + RA was characterized by RF, hypercomplementemia; SS + SLE was characterized by various antibodies to nucleic acids (nDNA, DNP (and anti-Sm, antinuclear factor (ANF) of homogenous and peripheral types of glow, hypercomplementemia. The main systemic manifestations of SD (arthritis, vasculitis) and a high activity of the process was associated with the presence of anti-Ro/La, and marked local manifestations of the dry syndrome--with antibodies to nDNA and dDNA. And vice versa in SS + SLE anti-nDNA antibodies correlated with anemia, serositis, nephritis, vasculitis and the presence of anti-Ro/La--with a comparatively mild renal pathology. The presence of high titres of RF in SB correlated with the absence of the adequate therapy, the presence of hypergammaglobulinemic purpura, weakly pronounced local manifestations; but a decrease in the titres of RF and an increase in the titres of ANF; anti-nDNA, anti-DNP in young patients with SD proved to be a prognostically unfavourable factor. The presence of CIC was associated with hypergammaglobulinemic purpura and affection of the eyes, and hypocomplementemia--with affection of the kidneys, joints and salivary glands in patients with SD.

Adolescent↗