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Biomedical subjects

Z Z Zhu

Publications and source records attributed to Z Z Zhu.

12 recordsLinked to original sources
PubMed1997

[Effect of sanhuang jiangtang recipe on insulin peripheral resistance in type II diabetics].

OBJECTIVE: To observe the effect of Sanhuang Jiangtang recipe (SHJT) on insulin peripheral resistance in type II diabetics. METHODS: Ninety-five patients with type II diabetics were randomly divided into two groups. Fifty-three cases of SHJT group were given orally decoction and tablets of SHJT for 4-6 months. The efficacy was compared with that of 42 cases treated with Glipizide as the control. Before and after treatment standard steamed bread meal test was performed to measure the insulin peripheral sensitivity, insulin release to glucose and insulin sensitivity index. RESULTS: (1) The total effective rates of improving insulin peripheral resistance and reducing blood sugar in SHJT group were 79.2% and 80.1%, which was equivalent to levels in the control group, but SHJT recipe was more effective in relieving symptoms of Qi deficiency and signs of blood stasis. (2) In SHJT group, the insulin peripheral sensitivity and insulin sensitivity index were significantly increased (P < 0.05 and P < 0.01), meanwhile the fasting blood sugar and blood sugar area were reduced (P < 0.05), but the change of insulin release to glucose was blunted. (3) The lowering of blood sugar in SHJT group was significantly negative correlated with the changing of degree of insulin peripheral sensitivity and index of insulin sensitivity (P < 0.01 and P < 0.05), but not with that of insulin area. CONCLUSIONS: It suggested that the treatment of SHJT recipe might decrease insulin peripheral resistance (partial reversal) by means of reducing hyperinsulinemia and improving insulin sensitivity.

Adult↗
PubMed1997

[Effects of supplemented taohe chengqi decoction in treating insulin resistance in rats with non-insulin dependent diabetes mellitus].

OBJECTIVE: To investigate the effect of Supplemented Taohe Chengqi Decoction (STHCQD) in treating non-insulin dependent diabetes mellitus (NIDDM). METHODS: The model of rats with NIDDM was formed with injection of streptozotocin and fed on high calorie diet to study the effects of STHCQD on the release of insulin mediator from liver cell membranes, the glucose oxidation in adipocytes as well as the insulin sensitivity. RESULTS: (1) Fasting serum glucose, serum insulin, intake of food and water were significantly decreased (P < 0.05-0.01) in STHCQD-treated diabetic rats as compared with untreated diabetic rats, while the insulin sensitivity was significantly increased (P < 0.05). (2) The liver cell membranes from STHCQD-treated diabetic rats released the quantity of insulin receptor which inhibited adenylate cyclase activity, but this effect was blunted in untreated diabetic rats (P < 0.05). (3) A significantly increased glucose oxidation in adipocyte of STHCQD-treated diabetic rats was found as compared with those of untreated diabetic rats (P < 0.05). CONCLUSIONS: STHCQD therapy increased sensitivity and responsiveness of target cells to insulin, i.e., it might decrease insulin resistance at receptor sites and postreceptor sites in rats with NIDDM, but could not reverse the insulin resistance.

Adenylyl Cyclases↗
PubMed1995

[Relationship between various syndrome-types and defect of erythrocyte insulin receptors in non-insulin dependent diabetes mellitus].

Fifty-seven patients of non-insulin dependent diabetes mellitus (NIDDM) were divided into various groups by Syndrome Differentiation in TCM and 18 cases of non-diabetes mellitus were taken as control. The relationship of Syndrome-types and defect of the erythrocyte insulin receptors were studied with the percentage of specific insulin binding to erythrocyte, number and average affinity of erythrocyte insulin receptors. The results showed: (1) The patients of NIDDM had defect of erythrocyte insulin receptors specified with decreased number of insulin receptors; (2)Mild defect of erythrocyte insulin receptors was found in Syndrome of Yin Deficiency and hyperactivity of Heat, but serious defect in the Syndrome of both Qi and Yin Deficiency, in the Syndrome of both Yin and Yang Deficiency. Above data suggested that the defect of erythrocyte insulin receptors was correlated with Syndrome-types of patients with NIDDM, the more serious Deficiency Syndrome, the more serious defect of erythrocyte insulin receptors.

Aged↗
PubMed1990

A seral epidemiological study of HIV transmitted through human seral gamma-globulin preparations.

In order to study the potential risk of transferring HIV through human seral gamma-globulin preparations (immunoglobulin), indirect immunofluorescent antibody test (IFA) and Western Blot (WB) assay were applied to 343 random samples (sera) with previous injection of imported human seral gamma-globulins (Ig) positive for Human Immunodeficiency Virus (HIV) antibodies between 1981-1987 for the detection of HIV antibodies. All results were negative and tests on all 23 controls who had previously received Ig made in China also gave negative results. However all 12 batches of imported Ig collected from the above-mentioned users, were positive for HIV antibodies when tested by WB and IFA. This study shows that under normal conditions, human seral gamma-globulin does not transmit HIV.

Adolescent↗
PubMed1990

[Inflammatory mechanisms in corneal ulceration].

A retrospective histologic and analytic study of 355 corneal ulcer specimens obtained from therapeutic keratoplasties indicated that, during active corneal dissolution, the polymorphonuclear white cells predominated at the site of stromal degradation. The presence of PMN cells in corneal tissue was harmful by releasing degradative lysosomal enzymes, thus playing an important role in the development of the corneal ulceration.

Cornea↗
PubMed1990

[Padded lamellar keratoplasty for the treatment of corneal perforation].

The authors introduced padded lamellar keratoplasty in the treatment of 62 eyes of corneal perforation, mostly ulcerative. The operation was successful in 61 eyes (98.4%) and 38.7% obtained useful vision of 0.05-1.5. The principle, operative procedure, advantages and possible complications were depicted.

Corneal Diseases↗
PubMed1989

[Rotational corneal auto-grafting].

Fifteen (15) cases of rotational corneal autografting were performed in patients with adherent leukoma, sequelae of anterior segment burns, corneal ulcer, and corneal fistula. The optical and cosmetic effects were good in 14 of the 15 eyes in which the grafts were clear in the pupil area. The indications, technique, advantages and shortcomings of this operation were discussed.

Adolescent↗