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Z Zdebski

Publications and source records attributed to Z Zdebski.

At least 19 recordsLinked to original sources
PubMed2005

Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia.

BACKGROUND: Several lines of evidence point to the dysfunction of the endothelial l-arginine-NO system in preeclampsia. We investigated the influence of dietary supplementation with l-arginine on blood pressure and biochemical measures of NO production in women with preeclampsia in prospective, randomized, placebo-controlled study. DESIGN: The 61 preeclamptic women on a standardized low nitrate diet received orally 3 g of l-arginine (n = 30) or placebo (n = 31) daily for 3 weeks as a supplement to standard therapy. The differences between the two groups in systolic (SBP), diastolic (DBP) and mean arterial blood pressures (MAP) as well as in plasma levels of selected aminoacids, plasma concentrations of nitrates/nitrites (NOx) and in 24-h urine NOx excretion were determined. RESULTS: After 3 weeks of treatment, values of SBP, DPB and MAP were significantly lower in the group taking l-arginine as compared with the placebo group (SBP: 134.2 +/- 2.9 vs. 143.1 +/- 2.8; DBP: 81.6 +/- 1.7 vs. 86.5 +/- 0.9; MAP: 101.8 +/- 1.5 vs. 108.0 +/- 1.2 mmHg, P < 0.01). Importantly, treatment with exogenous l-arginine significantly elevated 24-h urinary excretion of NOx and mean plasma levels of l-citrulline. Exogenous l-arginine did not influence plasma concentrations of l-arginine, l-ornithine and methylated arginines (ADMA, SDMA, L-NMMA). CONCLUSIONS: We conclude that in women with preeclampsia, prolonged dietary supplementation with l-arginine significantly decreased blood pressure through increased endothelial synthesis and/or bioavailability of NO. It is tempting to speculate that the supplementary treatment with l-arginine may represent a new, safe and efficient strategy to improve the function of the endothelium in preeclampsia.

Administration, Oral↗
PubMed2001

[Nitric oxide - one of the mechanisms that prevent changes that occur during pregnancy].

The aim of this paper is to outline actual opinions on the role of the Nitric Oxide (NO) as a significant point of the physiological changes of pregnancy and pathogenesis of hypertension in pregnancy, and premature labour. The principal of the structure, mechanism of action of endothelial cells, its coordinations with other mediators, up to date literature and the perspectives of the treatment was reviewed as well.

Antihypertensive Agents↗
PubMed2000

[The role of ultrasonographic evaluation of uterine cervix length and dilation for diagnosis and management of twin pregnancy].

OBJECTIVE: This study assesses ultrasonographic parameters concerning cervix length and cervical canal width of women with bigeminal pregnancy. The parameters mentioned proved to be useful while taking a right therapeutical decision i.e. using tocolysis or surgical treatment (cerclage). MATERIALS AND METHODS: This study included 52 women with bigeminal pregnancy. There were 14 women with the first pregnancy and 38 with the second and more pregnancies--ranging from 18 to 35 years of age. The negative obstetrics past and non-invasive treatment as well as surgical treatment were taken into consideration. 43 women were diagnosed using ultrasonographic examination. The cervix length and cervical canal width were checked every 7-14 days. In 9 of them the cerclage was done. RESULTS: In the group of women with cerclage 66.6% of pregnancies ended before the 37th week. The mean pregnancy duration was 29.4 weeks. 46.3% of infants were discharged in satisfactory condition. In the other group (tocolysis) 54.8% of pregnancies ended before 37th week. The mean pregnancy duration was 34.2 weeks. 72.7% of infants were discharged in satisfactory condition. CONCLUSIONS: The assessment of the length of the cervix and the width of the cervical canal in the bigeminal pregnancy by the case examination is performed in order to take proper therapeutical decisions i.e. tocolysis or surgical treatment.

Adult↗
PubMed2000

[Term delivery in twin pregnancy].

We analyzed the data on 55,839 births that taken place in 1998 year in the southeast region of Poland. The incidence of twin pregnancy was about 1%. A half of them delivered before 259 day of gestational age, the beginning of birth occurring norm for human. This means that onset of this norm for singleton pregnancies is the mean of 12 weeks births occurring norm (215-303 days of gestational age) for multifetal pregnancies simultaneously. The particular meaning has prevention of preterm delivery and in this case the computer-aided monitoring of pregnancy and prediction of birth date is a very useful invention.

Delivery, Obstetric↗
PubMed1996

Successful full-term pregnancy in a patient three and a half years after a heart transplant.

The patient is a 28 year old woman who received a heart transplant in 1992 secondary to hypertrophic cardiomyopathy with unremarkable post-operative course. In the period immediately post transplantation the patient was on a four-drug immunosuppressive regimen which was subsequently changed to standard three-agent therapy. This therapy was continued until the patient became pregnant. In the first trimester only Cyclosporine (CsA) was used, and thereafter, the patient was continued on the previous three agent regimen. Toward the end of pregnancy a rise in systolic pressure was observed, but the child was delivered by spontaneous vaginal delivery without complications in the 38th week of pregnancy. The newborn weighed 3320 g and was in good health. A sharp fall in the newborn CsA blood levels was observed post delivery reaching zero level on the third day of life. At the present time, both mother and baby are in good health, 6 weeks after delivery.

Adult↗
PubMed1993

Iodine deficiency in pregnant women in an area of moderate goiter endemia.

Low levels of iodine, observed in endemic goiter areas, decrease the synthesis of T3 and T4. This phenomenon is particularly dangerous during pregnancy when demand for thyroid hormones increases considerably. Iodine deficiency may cause brain tissue damage of varying degree, even cretinism in most severe cases. The aim of the study was to make an initial evaluation of TSH and thyroid hormone levels, thyroid volume, and urine iodine excretion in pregnant women. The group under study consisted of 46 women, inhabitants of Kraków region. Their mean age was 26.8 years, 18 were primiparas and 28 multiparas. All deliveries were physiologica, vaginal, within the biological norm of 281 +/- 22 days from the last menstrual period. The concentrations of T3, T4 and TSH were determined in maternal and umbilical blood. Urine iodine levels were measured in the patients. Mean body weight of the newborns was 3338 g, mean pregnancy duration 39.6 weeks, and mean Apgar score 9.9. The results for maternal blood were (mean, SD in parentheses): T3 1.5 ng/ml (0.4), T4 11.6 micrograms% (2.9), TSH 2.3 microU/ml (1.2), thyroid volume 27.8 ml (15.2), urine iodine level 34.99 micrograms/l (29.12), and for umbilical blood T3 0.59 ng/ml (0.1), T4 10.6 micrograms/dl (2.1), FT3 1.28 pm/l (1.1), FT4 15.6 pm/l (4.8), TSH 3.7 microU/ml (0.9). Urine iodine level in pregnant women was several times lower than normal. 80% of the women under study had enlarged thyroid glands. We conclude that investigations of the problem should be continued.

Adult↗
PubMed1989

[Effects of low-temperature treatment of pathologic changes of the cervix uteri].

The paper presents the course of treatment and results of therapy of pathological changes in the uterine cervix in 41 patients by means of cryotherapy (with the use of a cryotherapeutic apparatus UK-32 in which liquid nitrogen was used as a cryogenic fluid). Complete recovery in the form of typical stratified squamous epithelium was achieved in 95.3% of cases.

Adult↗
PubMed1989

[Effect of cryotherapy on pathological changes of the uterine cervix].

The paper presents the course of treatment and results of pathological changes in the uterine cervix in 41 patients who underwent cryotherapy by means of a cryotherapeutic apparatus UK-32, using liquid nitrogen as cryogenic fluid. Complete recovery in the form of typical stratified squamous epithelium was achieved in 95.3% of cases.

Adult↗
PubMed1989

[Influence of pregnancy on the healing of chronic gastric and duodenal ulcers. Role of endogenous epidermal growth factor].

The authors examined the influence of pregnancy on the healing of chronic gastric and duodenal ulcers in connection with pregnancy-induced changes of growth parameters of gastric-duodenal mucosa and changes in the level of endogenic EGF. Besides, the level of EGF was lowered by the resection of submandibular glands (sialadenectomy). Pregnancy caused an increase in the speed of the healing of gastric and duodenal ulcers, this effect being the result of the appearance of hyperplastic changes in the gastric-duodenal mucosa. This hyperplasia was the result of the increase in the level of endogenic EGF. Sialadenectomy decreased the level of EGF in the blood serum preventing total pregnancy hyperplasia of the mucosa in the stomach and partly in the duodenum, which resulted in the total abolition of favourable influence of pregnancy on the healing of gastric ulcers and reduction of the influence of pregnancy on the healing of duodenal ulcers. The results obtained show that the gastric and duodenal mucosa during pregnancy has an increased ability to regenerate, this ability resulting from the hyperplasia of the mucosa taking place in pregnancy, which is the effect of an increase in the level of endogenic EGF.

Chronic Disease↗
PubMed1989

[Measurement of blood flow in the umbilical artery of women with pregnancy complications].

The authors analysed the blood flow in the umbilical artery determining the Stuart coefficient in 118 pregnant women. The article presents the values of the coefficient in normal pregnancies (control group). In pathological pregnancy the authors found a deterioration of the umbilical flow in patients with diabetes and intrauterine fetal hypotrophia. In case of cardiac defects and hypertension the results obtained require further evaluation based on larger clinical material.

Female↗