PubMed Health⌕ Search

Biomedical subjects

Ze'ev Korzets

Publications and source records attributed to Ze'ev Korzets.

At least 19 recordsLinked to original sources
PubMed2006

Prehypertension and obesity in adolescents: a population study.

BACKGROUND: Current blood pressure (BP) classification is based on the recent recommendations of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC-7) and the 2003 European Society of Hypertension-European Society of Cardiology Guidelines for the Management of Arterial Hypertension. The JNC-7 introduced a new concept, prehypertension, and recommended health-promoting lifestyle modifications for these individuals. Obesity is also recognized as a major risk factor for the development of hypertension. We aimed to determine the prevalence of hypertension and obesity in a large cohort of adolescents and to assess whether prehypertension and body mass index (BMI) increase with increasing age. METHODS: A cross-sectional population-based study was performed using data collected during 1996 to 2002 in an army recruitment examination of 560,588 Israeli individuals 16.5 to 19 years of age. The subjects were divided according to gender and stratified by increasing 6-month intervals into five groups. Prehypertension was defined as BP 120 to 139 / 80 to 89 mm Hg. Overweight was defined as BMI 25 to < or = 30 and obesity as BMI >30 kg/m2. RESULTS: Mean systolic BP (SBP) and diastolic BP (DBP) were significantly higher in male subjects for all groups. By applying the JNC-7 criteria, 56.8% of male subjects and 35.8% of female subjects would be considered prehypertensive. There was a statistically significant increase in the mean SBP and DBP with age and BMI. Among male subjects 10.9% were overweight and 3.3% were obese; among female subjects, 11.1% were overweight and 3.2% were obese. The BMI did not increase with increasing age. The prevalence of prehypertension was significantly higher in obese subjects. CONCLUSIONS: Prehypertension is very common among Israeli adolescents. A substantial number of adolescents exhibit a BMI greater than normal. As both of these factors are known to be asssociated with increased cardiovascular risk, early institution of healthful lifestyle changes in a large proportion of this age group is recommended.

Adolescent↗
PubMed2006

Advanced glycation end products stimulate tumor necrosis factor-alpha and interleukin-1 beta secretion by peritoneal macrophages in patients on continuous ambulatory peritoneal dialysis.

BACKGROUND: Advanced glycation end products, formed by the non-enzymatic glycation of proteins with reducing sugars, are thought to play a pathogenetic role in the vascular complications of diabetes, uremia and atherosclerosis. 132-microglobulin is a major constituent of amyloid fibrils in dialysis-related amyloidosis. AGE1-modified beta2m has been found in amyloid deposits of long-term hemodialysis patients. AGE-modified 132m has also been shown to enhance chemotaxis and increase tumor necrosis factor-alpha and interleukin-1 beta secretion by circulating and tissue monocytes/macrophages. OBJECTIVES: To investigate the effect of AGE-modified 132m and AGE-human serum albumin on TNF-alpha and IL-1beta secretion by human peritoneal macrophages derived from patients on continuous ambulatory peritoneal dialysis. METHODS: Human PMO were isolated from peritoneal dialysis effluent of stable CAPD patients and were incubated for 24 hours with AGE-modified beta2m, beta2m, AGE-HSA, HSA or lipopolysaccharide. TNF-alpha or IL-1beta secretion was measured by enzyme-linked immunosorbent assay in cell-free culture supernatants. RESULTS: Both AGE-modified beta2m and AGE-HSA significantly increased TNF-alpha and IL-1beta secretion by human PMO in a dose-dependent manner (50-200 microg/ml). In contrast, beta2m or HSA had no such stimulatory effect on TNF-alpha secretion but had a small significant increase in IL-1beta secretion. CONCLUSIONS: AGE-modified beta2m promotes in vitro TNF-alpha and IL-13 secretion by human PMO of CAPD patients. Activation of these macrophages by AGE-modified beta2m may be a contributory factor to the morphologic changes and altered permeability of the peritoneal membrane in long-term CAPD.

Cells, Cultured↗
PubMed2003

Laparoscopic salpingectomy: the definitive treatment for peritoneal dialysis catheter outflow obstruction caused by oviductal fimbriae.

The successful maintenance of peritoneal dialysis depends on a well-functioning permanent peritoneal dialysis catheter. Catheter flow obstruction is a common cause of technical failure. It usually occurs as a result of catheter migration, omental or small bowel entrapment, or fibrin clots. Obstruction by oviductal fimbriae has only rarely been reported. We describe such a case in a 56-year-old woman in whom the obstructing fimbriae were released from the catheter on initial laparoscopy. However, shortly thereafter, recurring tubal impediment to flow made it necessary to perform laparoscopic bilateral salpingectomy. We suggest that in the absence of any future fertility issues, laparoscopic salpingectomy should be considered the procedure of choice in the management of this condition.

Catheters, Indwelling↗
PubMed2003

The "DRIL" procedure--a neglected way to treat the "steal" syndrome of the hemodialysed patient.

BACKGROUND: The ischemic "steal" syndrome complicates angio-access in a growing number of hemodialysed patients. Until now, operative attempts (fistula ligation or banding) to treat this problem have met with only limited success. OBJECTIVE: To assess the results of DRIL (distal revascularization-interval ligation) procedure in treating the "steal" syndrome. METHODS: A retrospective review (1996-2002) was conducted of all 11 patients who underwent the DRIL procedure in two tertiary care hemodialysis units. RESULTS: Two patients were excluded because of inadequate medical documentation. All of the nine patients remaining suffered from overt atherosclerotic disease, six had diabetic nephropathy and four were smokers. The arteriovenous access, which led to the "steal" syndrome, was proximally located in all (antecubital in 8, thigh area in 1). "Steal" symptoms included hand pain, paraesthesia, neurologic deficits and gangrenous ulcers. DRIL was technically successful in all patients. There were no perioperative deaths. Immediate and complete relief of pain was achieved in eight of the nine patients. One patient with gangrene later required a transmetacarpal amputation. No patient required hand amputation. During follow-up (range 1-26 months) hemodialysis was continued uninterruptedly using the problematic AVA in all patients. Thrombosis occurred in the AVA in only two patients after the DRIL procedure at 9 and 24 months postoperatively, respectively. Three patient deaths were unrelated to the DRIL. CONCLUSIONS: In selected patients the DRIL procedure is a safe and effective way to treat the "steal" syndrome. AVA patency is not compromised by this operation. Preoperative angiography, before and after manual compression of the AVA, is crucial for the proper selection of patients who will benefit most from the DRIL procedure.

Aged↗
PubMed2002

Fetal urinoma as a sign of a dysplastic kidney.

We describe a female neonate in whom a urinoma was first diagnosed at 20 weeks of gestation without any evidence of underlying urinary tract obstruction. The urinoma became apparent following the performance of a "bloody tap" amniocentesis. Sequential ultrasonography, both fetal and up to 3 months after birth, showed eventual resorption of the urinoma in parallel with the development of a shrunken, non-functioning kidney. Except for the onset of high-renin hypertension, which spontaneously remitted at 1 year of age, the baby's postnatal course was uneventful. Renal function was normal. The presence of a fetal urinoma as a sign of a dysplastic kidney is discussed.

Adult↗
PubMed2002

Ambulatory blood pressure monitoring in children with isolated haematuria.

Ambulatory blood pressure monitoring (ABPM) was performed in 29 children, ages 8.5-10.5 years (mean 11.6+/-3.0) with isolated haematuria (IH) and in 27 age, sex, weight and height matched healthy controls (C). Isolated haematuria was defined as >or=5 RBC/HPF on three separate urinalyses over a 3-month period with normal renal function, a normal appearing ultrasound examination of the kidneys and the absence of hypercalciuria. Haematuria had been documented for at least 3 years prior to ABPM. Daytime and nighttime periods were 0800-2200 and 2200-0800 hours, respectively. The total number of successful blood pressure readings was 21.8 and 20.7 per subject (90.0 and 86.1% of all attempted measurements) in IH and C, respectively. Mean 24-h, daytime and nighttime heart rate, mean arterial pressure, and systolic and diastolic blood pressure in IH did not differ from that of controls. Nocturnal dipping was present in all IH patients and was of equal magnitude to C (9.5 vs 8.4 and 13.7 vs 10.3% for average systolic blood pressure (SBP) and diastolic blood pressure (DBP) dips, respectively). We conclude that normal blood pressure values, as well as the circadian rhythm of blood pressure, are maintained in children with IH of at least 3 years' duration.

Blood Pressure↗
PubMed2002

Delayed carotid artery rupture in advanced cervical cancer--a dilemma in emergency management.

Carotid artery rupture in the setting of advanced carcinoma of the head and neck constitutes a surgical emergency. This report details three such patients, two of whom presented with profuse bleeding, the other with imminent rupture. Notably, our first patient ruptured 27 years after having had radiotherapy for carcinoma of the larynx. This patient had had no previous surgery and at operation no recurrent tumor was evident. In the other two patients, previous surgery had demonstrated tumor invasion of the carotid artery. The choice of therapy in this calamitous condition is controversial, the question being whether to resect and reconstruct or ligate the ruptured artery. Our three patients underwent ligation with no recurrence of bleeding and no neurological sequelae for a follow-up period of 5-36 months. Of paramount importance is the hemodynamic stabilization of the patient prior to being submitted to surgery. Our results favor ligation rather than resection and reconstruction as the procedure of choice in this difficult predicament.

Aged↗