PubMed Health⌕ Search

Biomedical subjects

Ze-qin Ren

Publications and source records attributed to Ze-qin Ren.

7 recordsLinked to original sources
PubMed2006

[Devoting much attention to further understanding the definition of glaucoma].

This article is intended to briefly introduce the latest new trends and the overall current situation surrounding the definition of glaucoma. This article also summarizes the difficulties in understanding the definition of glaucoma. Included is a theoretical discussion of how to differentiate the traditional and modern concepts of glaucoma and how to make glaucoma classification clinically practicable and understandable.

Glaucoma↗
PubMed2006

[The interrelationship between the sectorial disc and the visual field changes in patients with normal tension glaucoma].

OBJECTIVE: To investigate the changes of the sectorial discs and visual fields, and their interrelationships in patients with normal tension glaucoma (NTG). METHODS: 26 patients with NTG were undergone the optic nerve and visual field examinations with HRT-II and HFA II in a time interval of less than 5 months. The parameters in the study including cup shape measure (CSM), rim area (RA), rim volume (RV), mean cup depth (MCD) and cup volume index (CVI) were compared between the global discs and the sectorial discs in eyes with the evidences of preperimetric or early visual field defect (MD < or = 4 dB). The CVI was proposed to be equal to CV/(DA x MCD + RA x RNFLT), where DA was disc area and RNFLT was retinal nerve fiber layer thickness. The linear correlations were evaluated between the visual field MD and each of 5 parameters in sectorial discs. RESULTS: The sectorial disc areas were mostly in correspondence to the damaged hemifields (CVI: 92.68%, RA: 87.80%, RV: 82.93%). In addition, a correlation was seen for CSM and MCD (63.41% and 53.66%; chi2 = 23.17, P < 0.05). The comparison between preperimetric and early defects were significantly difference (t = 1.735 approximately 6.536, P < 0.05 approximately P < 0.05, one-sided t test). The correlation between CSM and MD was negative (r = -0.3002, P > 0.05), however the positive correlation was demonstrated in RA versus MD (r = 0.3105, P < 0.05). CONCLUSION: The examination of the 5 parameters of sectorial discs had even closer relationship than those of global discs scanning in the detection of early vision field defect and it is valuable in diagnosis of early glaucoma.

Adult↗
PubMed2005

[Statistical quality requires improvement in ophthalmic research].

The improper use of statistical analysis method and inadequate quality of experimental design are common in ophthalmic research. These problems originated from ignoring the importance of statistics or have a bias against the statistics by the researcher. Therefore, the misunderstanding of statistics must be cleared up, it is important for the researcher to familiar with statistical knowledge, instead of simply relying on the cooperation with statistics specialists. Researcher should devote much attention to the study of statistics and enhance the ability to apply it in practice. Statistics is not only one of the supports of evidence-based medicine, but it is also very important in keeping sustainable scientific development of science.

Ophthalmology↗
PubMed2005

[Clinical observation of needle revision and 5-fluorouracil subconjunctival injection on the dysfunctional filtering blebs].

OBJECTIVE: To investigate the efficacy of needle revision with 5-fluorouracil (5-FU) on the dysfunctional filtration blebs after trabeculectomies and to assess the factors that may impact the success. METHODS: Fourty eyes of 34 patients underwent the needle revision of the malfunctional blebs with 5-FU at clinic visits in 2 - 8 weeks immediately after trabeculectomies and were followed up for 12 weeks. RESULTS: After revision through needling procedures, the blebs were diffused and elevated in 26 eyes, thinned and multisystem in 9 eyes, thickened and focalized or invisible in profile in 5 eyes. Intraocular pressures (IOPs) were significantly (P < 0.01) lowered from (23.6 +/- 2.1) mm Hg (1 mm Hg = 0.133 kPa) of pre-needling to (16.3 +/- 2.9) mm Hg of post-needling in 35 functional filtering blebs. The Kaplan-Meier survival curve for the 40 eyes showed a success rate of (87.51 +/- 5.23)% within the follow-up time. Logistic regression did not show significant difference in needle revision among the types of glaucoma, the history of intraocular surgery, and the ages of patients. However, poorer responses were observed following greater intervals of needling operation from previous trabeculectomy (P = 0.046). The time interval for the median efficacy level is 5.9 weeks. Subconjunctival hemorrhage occurred in 6 eyes during the needle revision, and no other post-needling complications were found during the follow-up time. CONCLUSIONS: The needle revision combined with 5-FU is an effective, safe, and simple method of improving early dysfunctional filtration blebs after trabeculectomies. The success rate of needle revision was about 50% at 6 weeks and the delay of needle revision may result in poor responses.

Adult↗
PubMed2003

[Detection of mtDNA 11778 (G-->A) point mutation in a family with Leber's hereditary optic neuropathy by site-specific polymerase chain reaction].

OBJECTIVE: To find a simple, fast, accurate, and quantitative PCR-based method for mutation detection, so as to identify mitochondrial DNA 11778 G-->A point mutation in patients with Leber's hereditary optic neuropathy (LHON). METHOD: On the basis of sequencing of mtDNA from LHON proband, M primer for mutation and N primer for normal were designed to be coupled with reverse primer respectively. Specific PCRs were done on an amplifying condition with high stringency such as a well controlled annealing temperature, low Mg2+ concentration and less thermal cycles. The objective pedigree includes 10 individuals, were against 40 normal control persons. RESULTS: Different ratios of indicative mtDNA 11778A-->G mutation were checked out from the proband, affected maternal members and a 10 year-old boy (up to now no appearance yet), whereas not appeared on normal spouses, paternal offsprings in the family, neither did on 40 controls. CONCLUSION: This site-specific PCR method is a kind of general mutation analysis way, without the restriction of existence of endonuclease site. It can be applied for the gene diagnosis of known-mutation hereditary diseases such as LHON.

Adult↗