Biomedical subjects

Zeev H Arinzon

Publications and source records attributed to Zeev H Arinzon.

2 recordsLinked to original sources

PubMedDate not supplied

Surgical management of spinal stenosis: a comparison of immediate and long term outcome in two geriatric patient populations.

This retrospective study was performed to assess and compare the immediate safety and long term outcome of surgical decompression of spinal stenosis when performed for geriatric patients aged 65-74 years (Group A) and those >75 years (Group B) of age. Some 283 patients were studied (179 and 104 patients in Groups A and B, respectively). The mean follow-up time was 41.5 months (range: 9-115) and 42.9 months (range: 9-106) for Groups A and B, respectively. Within both treatment groups, there was a significant (P<0.0001) subjective improvement in low back and radicular pain, as well as the ability to perform daily activities. When compared to preoperative levels, the oral scores for pain while performing daily activities were significantly (P<0.001) improved in both treatment groups. The overall postoperative complication rate was similar between the groups. Age is not a contraindication for decompressive lumbar spine surgery. However, since both Group A and B patients are likely to suffer minor perioperative complications, increased vigilance and careful monitoring are essential for this high risk population.

Activities of Daily Living↗

PubMedDate not supplied

Delayed recurrent SIADH associated with SSRIs.

BACKGROUND: Depression is a common problem in elderly patients and is frequently treated with selective serotonin-reuptake inhibitors (SSRIs). OBJECTIVE: To report a case of delayed recurrent hyponatremia after switching from one SSRI to another. CASE SUMMARY: An 87-year-old depressed woman began treatment with fluvoxamine. One week later, she was diagnosed with hyponatremia, most likely syndrome of inadequate antidiuretic hormone. Following discontinuation of fluvoxamine, the serum sodium concentration normalized. Later, she began treatment with paroxetine. Sixteen months after initiating paroxetine, she developed symptomatic recurrent hyponatremia. After paroxetine was discontinued, the sodium concentration normalized. DISCUSSION: In this case, unlike those previously reported, hyponatremia recurred 16 months after a different SSRI was initiated. The Naranjo probability scale indicates a probable relationship between recurrent hyponatremia and paroxetine. The mechanism of SSRI-induced hyponatremia is multifactorial. CONCLUSIONS: This case illustrates that replacement of one SSRI with another can cause delayed, recurrent hyponatremia in elderly patients. Plasma sodium concentrations must be monitored, not only in the first weeks of treatment, but throughout the full course.

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