Analysis of element content in scalp hair of healthy people and breast-cancer patients with SEM/EDX method.
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Breast Neoplasms↗
Biomedical subjects
Zeki Yilmaz
Publications and source records attributed to Zeki Yilmaz.
Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs.
We designed this study to determine whether serum free and phospholipid-bound choline concentrations change after surgery or methylprednisolone treatment in dogs and rats. In dogs, serum free and phospholipid-bound choline concentrations were decreased by 29% and 17% immediately after abdominal-pelvic surgery under xylasine+ketamine anesthesia, respectively, and both remained low for 24 h. Serum cortisol was elevated after surgery. The elevation in serum cortisol was inversely correlated with the decreases in free (r=-0.737; P<0.001) and phospholipid-bound (r=-0.771; P<0.001) choline concentrations. After methyprednisolone administration (5-20 mg/kg) free and phospholipid-bound choline concentrations decreased in a dose- and time-dependent manner. In rats, either surgery or methylprednisolone failed to alter serum free choline concentrations while phospholipid-bound choline decreased after surgery. These data show that the decrease in serum choline after surgery results from the increase in circulating glucocorticoids.
Animals↗
Use of olive oil based emulsions as an alternative to soybean oil based emulsions in total parenteral nutrition and their effects on liver regeneration following hepatic resection in rats.
BACKGROUND/AIM: The main objective of this study was to compare the effects of olive oil to those of soybean oil on liver tissue regeneration following hepatic resection in rats. METHODS: Seventy albino Wistar rats were randomly assigned to seven groups which contained 10 rats each. Group 1 was the sham-treated group; groups 2 and 3 received total parenteral nutrition (TPN) containing soybean oil lipid emulsions (20% Lipofundin MCT/LCT) for 48 or 72 h; groups 4 and 5 received TPN containing olive oil (80%)/soybean oil (20%) lipid emulsions (ClinOleic 20%) for 48 or 72 h; group 6 was the control group for 48 h, and group 7 was the control group for 72 h. TPN was given via internal jugular vein, and 70% hepatic resection was performed in the study groups. In addition, hepatic resections with no TPN were performed in the control groups, except the sham group. Relative liver weight, mitotic index, proliferating cell nuclear antigen labeling index, and carnitine levels in liver tissue samples were used to assess hepatic regeneration. Thiobarbituric acid reactive substances were measured as an index of lipid peroxidation and oxidative tissue damage. Alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were parameters for the liver function. RESULTS: The relative liver weight increased significantly with minimal hepatosteatosis in the olive oil treated groups. Lipid peroxidation significantly decreased with near-normal serum levels of the liver function parameters in the olive oil/soybean oil treated groups, and mitotic index and proliferating cell nuclear antigen labeling index reached their maximum level in rats receiving TPN containing any kind of lipid emulsions for 48 h following resection. CONCLUSIONS: The use of olive oil/soybean oil lipid emulsions in TPN has important beneficial effects on the liver regeneration, and the antioxidant properties of olive oil originating from its natural components indirectly contribute to the liver regeneration in rats.
Animals↗
Evidence of bovine immunodeficiency virus in cattle in Turkey.
A seroepidemiological study of bovine immunodeficiency virus (BIV) and bovine leukemia virus (BLV) infections was conducted in four different cattle herds in Turkey. A total of 300 blood samples were analyzed and 12.3% were found to be positive for anti-BIV p26 antibodies by Western blot analysis and 1.6% positive for anti-BLV gp51 antibodies by an immunodiffusion test. BIV infection was confirmed with the detection of BIV-provirus DNA using the nested polymerase chain reaction. This is the first evidence for the presence of BIV in cattle in Turkey.
Animals↗
Comparison of the results of early, delayed and elective surgery in biliary pancreatitis.
BACKGROUND/AIMS: To evaluate the results of the patients who underwent surgery for biliary pancreatitis, with respect to timing of operation. METHODS: 192 Patients underwent surgery for biliary pancreatitis between January 1990 and December 1999. The patients were retrospectively separated into three groups: early surgery (within 72 hours after admission), delayed surgery (between 3 and 15 days after admission) and elective surgery (after 15 days). RESULTS: There were 98 patients in the early surgery group, 46 in the delayed surgery group and 48 in the elective surgery group. The number of Ranson's criteria present was between 3 and 5 in 58.2% of the cases in the early surgery group and in 54.3% of the cases in the delayed surgery group, whereas 62.5% of the cases in the elective surgery group had 0-2. APACHE II score was in the 6-10 range in 43.9% of the cases in the early surgery group and in 39.1% of the cases in the delayed surgery group, whereas 66.7% of the cases in the elective surgery group had between 0 and 5. The most frequent operations in the early and delayed surgery groups was cholecystectomy, common bile duct exploration, and T-tube placement (60.2% and 69.6%, respectively), whereas it were laparoscopic cholecystectomy in the elective surgery group (66.7%). Pancreatitis-related complication rates in the early, delayed and elective surgery groups were 20.4%, 17.4% and 8.3%, respectively. Mortality rates were 5.1% and 4.3% in the early and delayed surgery groups, respectively. There was no deaths in the elective surgery group. CONCLUSION: In biliary pancreatitis, surgery should not be considered as a primary option until the resolution of the pancreatic inflammation and its systemic effects. It should be employed only when the clinical picture does not ameliorate in spite of conservative treatment.
APACHE↗