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Zenon Halaba

Publications and source records attributed to Zenon Halaba.

6 recordsLinked to original sources
PubMed2006

Longitudinal changes in ultrasound measurements: a parallel study in subjects with genetic disorders and healthy controls.

Disturbances in skeletal status in subjects with genetic disorder may increase their fracture risk. The aim of the study was longitudinal observation of phalangeal speed of sound changes across the bone over a period of 2 y in 24 patients (14 boys and 10 girls, mean age 9.63 +/- 1.8 y.) and 24 age-matched healthy controls (14 boys and 10 girls, mean age 9.65 +/- 1.71 y.). Weight and height did not differ between patients and controls at baseline and follow-up. Patients with the following disorders were evaluated: 7 with Down syndrome, 6 nonspecific mental retardations of unknown etiology, 5 Martin-Bell syndrome and 6 with other diseases. In patients and controls, no factors potentially influencing bone metabolism (except for genetic disorder) were present. Bone status was assessed by quantitative ultrasound at hand phalanges using DBM Sonic 1200 (IGEA, Carpi, Italy), which measures amplitude-dependent speed of sound (Ad-SoS [m/s]). At baseline, Ad-SoS and Z-score were significantly lower in patients than in controls (1892 +/- 51 m/s versus 1936 +/- 43 m/s, p < 0.01 and -1.47 +/- 1.43 versus -0.14 +/- 1.04, p < 0.001, respectively. In follow-up, Ad-SoS and Z-score increased significantly in patients (1892 +/- 51 m/s to 1934 +/- 48 m/s, p < 0.0001 and -1.47 +/- 1.43 to -0.76 +/- 1.00, p < 0.01, respectively) and in controls (1936 +/- 43 m/s to 1976 +/- 60 m/s and -0.14 +/- 1.04 to 0.31 +/- 1.08, p < 0.05, respectively). Follow-up Ad-SoS and Z-Score were significantly lower in patients (p < 0.01). Longitudinal changes in Ad-SoS, Z-score weight did not differ between patients and control, and height increased more in controls (13.2 +/- 2.8 cm versus 11.4 +/- 5.9 cm, p < 0.05)+). In patients, Ad-SoS increased by 42 m/s (2.22%), and in controls increased by 40 m/s (2.07%). Difference in Ad-SoS between patients and controls was 44 m/s at baseline and 42 m/s at follow-up. Using the value of the least significant change (LSC = 20.5 m/s), in 16 patients (67%) and in 18 controls (75%) Ad-SoS showed an increase greater than the LSC, in one control (4%) a decrease greater than the LSC and in rest of subjects studied remained unchanged (33% patients and 19% controls) over a period of observation. In conclusion, despite comparable improvement in measured ultrasound parameter in patients and controls observed over a study duration, the difference between them remained stable.

Bone Density↗
PubMed2006

Quantitative ultrasound and peripheral bone densitometry in patients with genetic disorders.

The aim of the study was comparison of quantitative ultrasound and densitometric peripheral measurements in subjects with genetic disorders. The study included 52 subjects (35 boys and 17 girls) in mean age 13.1 +/- 4.8 y. Patients with following disorders were evaluated: Down syndrome (n = 21), Martin-Bell syndrome (n = 14) and other (n = 17). There were no additional factors potentially influencing bone metabolism. Bone status was assessed by quantitative ultrasound at the hand phalanges using DBM Sonic 1200 (IGEA, Italy), which measures amplitude-dependent speed of sound (Ad-SoS [m/s]) and bone densitometry at the calcaneus and forearm by the use of PIXI (GE, USA), which measures bone mineral density (BMD, g/cm2). Ad-SoS correlated significantly with forearm and calcaneus BMD in the whole group (r = 0.66, p < 0.000001 and r = 0.51, p < 0.0001, respectively), in females (r = 0.58, p < 0.05 and r = 0.5, p < 0.05) and in males (r = 0.70, p < 0.000001 and r = 0.54, p < 0.001). Calcaneus BMD correlated with wrist BMD in the whole group, in females and males: r = 0.66, p < 0.000001, r = 0.67, p < 0.01 and r = 0.75, p < 0.0001, respectively. These coefficients of correlation were compared and did not reveal significant differences in the whole group and in the gender subgroups. ROC analysis of Ad-SoS values versus calcaneus and forearm BMD showed area under curve 0.89 for forearm BMD and 0.79 for calcaneus BMD (subjects with Ad-SoS T-score below -3.2 were considered as abnormal). Age correlated significantly with Ad-SoS, forearm and calcaneus BMD (r ranged from 0.53 to 0.9, p from 0.05 to 0.000001). In all patients and males, age more strongly influenced Ad-SoS than calcaneus BMD (p < 0.05). Also, body weight and height correlated significantly with Ad-SoS, forearm and calcaneus BMD, except for correlation between forearm BMD and height in female patients (r from 0.58 to 0.84, p < 0.05). Generally, in multiple stepwise regression analysis of age and body size on skeletal parameters, age had positive influence, and body size was a positive or a negative factor. In conclusion, both quantitative ultrasound and peripheral densitometry may be recommended for the assessment of skeletal status in subjects with genetic disorders, although measurements of phalanges seem to be more sensitive for detecting age-related bone changes.

Absorptiometry, Photon↗
PubMed2004

Skeletal status in adolescents with end-stage renal failure: a longitudinal study.

In a longitudinal study, bone status was assessed in adolescents and young adults aged 15.3+/-3.4 years at the onset of the study with end-stage renal failure (ESRF). The group consisted of 18 subjects (11 females and seven males), of whom nine patients were on hemodialysis and nine patients on peritoneal dialysis. Six patients were previous or current glucocorticoid (GCS) users. Renal failure was recognized before 6.1+/-4.1 years, and dialysis was performed for 3.0+/-2.0 years. Follow-up took placed 8.6+/-0.8 and 21.7+/-2.5 months later, and the following data were collected: bone mineral density (BMD) at the spine (s-BMD) and total body (TB-BMD) using DPX-L (Lunar, USA); quantitative ultrasound by DBM 1200 (IGEA, Italy) at the hand phalanges (Amplitude-dependent Speed of Sound, Ad-SoS), serum concentration of i-PTH, total calcium, ionized calcium and phosphate. Tanner stages were also evaluated. The mean values of BMD measurements and Ad-SoS were stable during a period of observation, and a mean Z-score for TB-BMD was significantly lower at the third versus baseline value (-1.87+/-1.75 versus -1.49+/-1.53, P<0.05). Z-scores for s-BMD and Ad-SoS decreased non-significantly. Changes in s-BMD and TB-BMD Z-scores were influenced by changes in body size and changes in biochemical parameters, and a change in Ad-SoS Z-score was not dependent on these factors. The values of second (P<0.05) and third (P<0.01) s-BMD Z-score were significantly lower in GCS treated subjects, and longitudinal change in spine Z-score was greater in GCS treated patients versus others (P<0.05). Duration of ESRF, duration and type of dialysis and gender did not influence skeletal variables. Skeletal measurements correlated significantly with Tanner stages (besides the correlation with Ad-SoS in the first measurement, r ranged from 0.5 to 0.72, P<0.05), and changes in Tanner stages observed over a period of observation did not correlate with changes in skeletal variables. Among laboratory variables, the following non-significant tendencies to change were observed: serum concentration of i-PTH and phosphate increased, and total and ionized calcium decreased. In conclusion, adolescent subjects with ESRF treated with dialysis showed stable mean values of skeletal measurements, and these were expressed as Z-scores, a tendency to drop was observed. The lack of an increase observed in normal healthy subjects of the same age, and low values in Z-scores, indicates that skeletal status is seriously affected in subjects with ESRF.

Absorptiometry, Photon↗