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Biomedical subjects

Zh M Salmasi

Publications and source records attributed to Zh M Salmasi.

16 recordsLinked to original sources
PubMed2005

[Immunologic disorders in pathogenesis of chronic generalized parodontitis].

Systemic immunity was studied in patients with chronic generalized parodontitis. This group of patients had distinct changes in immunologic system: depression of T- and stimulation of B-cellular immunity without accumulation of plasma cells and initiation of effective humoral response. Increased peripheral blood number of lymphocytes expressing induction of apoptosis CD95 receptors and ligand for this receptor CD95L (Fas-L) can lead to intensification of lymphocyte apoptosis and may be the reason for T-cell deficit development. The results of the study confirm the important role of immune system disturbances in pathogenesis of chronic generalized parodontitis.

Apoptosis↗
PubMed2004

Taban-Arshan: immunocorrector in atopic bronchial asthma.

Taban-Arshan extract decreased expression of T-lymphocyte activation markers, normalized T-cell-mediated immunity, and suppressed increased activity of natural killer receptors during culturing with lymphocytes of patients with atopic bronchial asthma. Taban-Arshan extract normalized activation processes in the B-cell immunity and stimulated expression of receptors of activation-induced apoptosis.

Adult↗
PubMed1983

[Suppressor activity changes in human T-lymphocytes as affected by adreno- and cholinotropic substances].

The influence of oxyfedrine (beta-adrenoagonist) and carbocholine (cholinoagonist) on the functional activity of Con A-induced suppressor T-lymphocytes in healthy persons and in bronchial asthma patients was studied. Oxyfedrine at a concentration of 10 micrograms/ml (10(-5) M) was shown to induce a significant increase in the suppressing activity of both normal lymphocytes and those obtained from bronchial asthma patients. The repeated incubation of lymphocytes with carbocholine at a concentration of 5 micrograms/ml (10(-6) M) led to the removal of the suppressing effect of normal lymphocytes and to the increase of the activating effect of lymphocytes from bronchiae asthma patients.

Asthma↗
PubMed1981

[Suppressant effect of oxyfedrine on development of anaphylaxis in experimental animals].

Oxyfedrine (ildamen) which stimulates beta-adrenoreceptors of smooth muscles in concentrations increasing the tissue content of cAMP produced a dose-dependent inhibition of anaphylactic bronchospasm and contractions of the guinea-pig intestine induced by administration of ovalbumin. The results obtained provide evidence in favour of oxyfedrine use for suppression of immediate type allergic reactions with the involvement of smooth muscles.

Anaphylaxis↗
PubMedDate not supplied

[Mechanisms of immunotropic effect of the drug composition Taban-Arshan (Tibet medicine) on lymphocytes of patients with early rheumatoid arthritis and atopic bronchial asthma].

The extract of the Tibetan medicine Taban-Arshan corrects changes of the immune system in inflammatory diseases--rheumatoid arthritis and atopic bronchial asthma. An immunomodulating effect of the drug consists in its ability to suppress hyperactivation of lymphocytes by normalization of expression of basic activation antigens.

Adult↗
PubMedDate not supplied

[Activation markers of lymphocytes as indicators of immune system dysregulation in inflammation].

Three groups of activation antigens (receptors) of human peripheral blood lymphocytes (CD23, CD54--functional activation antigens, CD25 and CD71--early activation antigens and HLA-DR and CD95--late activation antigens) were studied in patients with inflammatory diseases of different types. All kinds of inflammation are independent of etiological factors and are associated with immune system activation. Inflammation induced by tissue injury or invasion of nonspecific microorganisms leads to a rapid rise in the count of lymphocytes expressing early markers of activation. Inhibition of inflammation occurs with a significant rise in peripheral blood lymphocytes with receptor of activation apoptosis CD95 (Fas-antigen). High number of lymphocytes with early markers of activation in line with high number of blood CD95+ lymphocytes take place in allergic and autoimmune diseases for a long time. Abnormal regulation of activation processes in lymphocytes in allergic and autoimmune diseases consists in the absence of lymphocyte activation inhibition in spite of high expression of CD95.

Adolescent↗
PubMedDate not supplied

[Mechanism of action of saventol in experimental anaphylaxis].

The mechanisms of the antianaphylactic effect of Saventol, a drug synthesized in the USSR, were studied on various experimental models. It was established that both in experiments on isolated organs and when given in injections to animals in vivo, Saventol produced a marked dose-dependent antianaphylactic effect. The results allow the antianaphylactic effect of Saventol to be linked with its antimediator effect realized through beta 2-adrenoceptors.

Albuterol↗
PubMedDate not supplied

[Mechanisms of disorders of immunoregulatory lymphocyte function in the atopic form of bronchial asthma].

Peripheral lymphocytes from 36 patients were used to study pathogenetic mechanisms of development of atopic bronchial asthma (ABA), which are associated with regulatory dysfunction of T lymphocytes. Models of determining immunoregulatory lymphocytic subpopulations (CD4+ and CD8+) and assessing the function of concanavalin A-induced immunoregulatory lymphocytes indicated that the reception of the immune mediators IL-2 and alpha-interferon was impaired in ABA patients. The paper gives the data on a significant drastic decrease in cAMP concentrations and an increase in cAMP levels in the peripheral lymphocytes in the patients. The findings suggest that there is an impaired turnover of cyclic nucleotides in the lymphoid cells of patients with atopy.

Adult↗