Using beta-lactamase to trigger supramolecular hydrogelation.
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Catalysis↗
Biomedical subjects
Zhimou Yang
Publications and source records attributed to Zhimou Yang.
A biocompatible method of decorporation: bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood.
We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.
Biocompatible Materials↗
Using enzymatic reactions to enhance the photodynamic therapy effect of porphyrin dityrosine phosphates.
This paper reports the synthesis and photodynamic therapy (PDT) effect of a porphyrin derivative containing tyrosine phosphate, which promises a new, useful approach to develop PDT agents.
Cell Survival↗
The first pamidronate containing polymer and copolymer.
Here we report the synthesis, characterization and hydrogelation of polymers consisting of pamidronate, a useful therapeutic agent.
Diphosphonates↗
Using a kinase/phosphatase switch to regulate a supramolecular hydrogel and forming the supramolecular hydrogel in vivo.
We have designed and synthesized a new hydrogelator Nap-FFGEY (1), which forms a supramolecular hydrogel. A kinase/phosphatase switch is used to control the phosphorylation and dephosphorylation of the hydrogelator and to regulate the formation of supramolecular hydrogels. Adding a kinase to the hydrogel induces a gel-sol phase transition in the presence of adenosine triphosphates (ATP) because the tyrosine residue is converted into tyrosine phosphate by the kinase to give a more hydrophilic molecule of Nap-FFGEY-P(O)(OH)(2) (2); treating the resulting solution with a phosphatase transforms 2 back to 1 and restores the hydrogel. Electron micrographs of the hydrogels indicate that 1 self-assembles into nanofibers. Subcutaneous injection of 2 in mice shows that 80.5 +/- 1.2% of 2 turns into 1 and results in the formation of the supramolecular hydrogel of 1 in vivo. This simple biomimetic approach for regulating the states of supramolecular hydrogels promises a new way to design and construct biomaterials.
Adenosine Triphosphate↗
Supramolecular hydrogels based on beta-amino acid derivatives.
Here we report on a new class of supramolecular hydrogels based on dipeptides that consist of beta-amino acids, which may confer proteolytic resistance to the hydrogels for biomedical applications.
Journal Article↗
Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds.
Two types of therapeutic agents, which have discrete yet complementary functions, self-assemble into nanofibers in water to formulate a new supramolecular hydrogel as a self-delivery biomaterial to reduce the toxicity of uranyl oxide at the wound sites.
Animals↗
Synthesis and cellular uptake of porphyrin decorated iron oxide nanoparticles-a potential candidate for bimodal anticancer therapy.
This paper reports the synthesis, characterization, and cellular uptake of the conjugate of porphyrin and iron oxide nanoparticles, which may lead to a bimodal anticancer agent that can be used in the combinational treatment of photodynamic therapy (PDT) and hyperthermia therapy (HT).
Antineoplastic Agents↗
Heterodimers of nanoparticles: formation at a liquid-liquid interface and particle-specific surface modification by functional molecules.
On the basis of a fundamental property of nanoparticles, the self-assembling at a liquid-liquid interface to form "colloidosomes", a heterogeneous reaction takes place on the exposed surface of the nanoparticles to produce the heterodimers of two distinct nanospheres, which can be modified by two different functional molecules in a particle-specific manner.
Dimerization↗
Molecular recognition remolds the self-assembly of hydrogelators and increases the elasticity of the hydrogel by 10(6)-fold.
Addition of vancomycin (1, the receptor) to the supramolecular hydrogel of self-assembled pyrene-d-Ala-d-Ala (2, the ligand) increases the storage modulus of the hydrogel of 2 by about 106-fold. Rheology, microscopy, and spectroscopy investigations suggest that the two-dimensional polymers, formed by the ligand-receptor interaction between 1 and 2, and the self-dimerization of 1, are mainly responsible for the observed dramatic increase in elasticity.
Biomimetic Materials↗
A simple visual assay based on small molecule hydrogels for detecting inhibitors of enzymes.
Here we report a simple approach to develop assays based on the hydrogelation of small molecules for quick detecting inhibitors of enzymes.
Enzyme Inhibitors↗
Small molecule hydrogels based on a class of antiinflammatory agents.
Here we report small molecule hydrogels formed by the combination of two N-(fluorenyl-methoxycarbonyl) amino acids, which belong to a novel class of antiinflammatory agents.
Amino Acids↗
Supramolecular hydrogels respond to ligand-receptor interaction.
N-(Fluorenyl-9-Methoxycarbonyl) dipeptides form supramolecular hydrogels via hydrogen bonding and hydrophobic interactions. These hydrogels respond to a ligand-receptor interaction as well as to thermal or pH perturbation and also exhibit chiral recognition.
Amino Acids↗