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Zofia Niemir

Publications and source records attributed to Zofia Niemir.

5 recordsLinked to original sources
PubMed2005

[Hematologic parameters in Polish centenarians].

We undertook this study to characterize the haematological indices in centenarian subjects who should be an excellent group to study the mechanisms of physiological aging. This study is a part of the Polish Centenarians Program co-ordinated by the International Institute of Molecular and Cell Biology in Warsaw. We examined 89 subjects aged 100 to 111 (14 males and 75 females). Mean values of all haematological parameters were within the normal range in females. In males, haemoglobin level (Hb), red blood cell count (RBC) and hematocrit (Hct) were slightly lower than WHO references (12.7 +/- 1.3 g/dl, 4.10 +/- 0.48 M/ml and 38.4 +/- 3.8%, respectively). However, anaemia was more frequent in females than in males (57.1% vs 29.1%, p < 0.05). In females with anaemia there was a tendency to decrease its severity with age. In the oldest group (aged 105-111 years) Hb and Hct had a tendency for lower values vs the youngest group (100-101 years) (10.1 +/- 1.8 g/dl vs 11.6 +/- 0.1 g/dl, p = 0.067 and 30.9 +/- 5.0% vs 35.0 +/- 0.3%, p = 0.067). Additionally, in the youngest group there were three females with severe anaemia (Hb < 9.0 g/dl) whereas in the oldest group all females with anaemia had Hb above 11.0 g/dl. In males the analysis was not undertaken because of small group of studied subjects. In conclusion, anaemia seems to be a relatively common problem in studied centenarians. Severe anaemia seems to be an eliminating factor in centenarian women.

Age Factors↗
PubMed2004

Reproducibility of the measurements of creatinine clearance in patients with a stable renal function.

In everyday practice the measurement of creatinine clearance (CCr) is used for the evaluation of the renal function. Since large body of evidence points to the inaccuracy of this test, we decided to check whether a repeated measurement of CCr might improve the assessment of the glomerular filtration rate. The study comprised 233 subjects, 105 females and 128 males, aged 22-80 years (mean age: 50.8 +/- 12.8 years) with the history of renal stones and a stable renal function, e.g. without changes in plasma creatinine. In every patient CCr was measured twice. Thereafter, all studied subjects were sorted by the increasing absolute values of the difference between two measurements of CCr e.g. as the difference between two measurements of CCr with omitted sign (absDCCr). Then, they were divided into 3 groups corresponding to the tertiles of absDCCr (tertile = 1/3). When the two values of CCr were compared among all patients, the mean difference between them (DCCr) was only 1.51 +/- 26.86 ml/min. The values of the individual DCCr varied, however, from -122.2. ml/min to 69.3 ml/min. As far as sex, age and height were concerned, there were no differences between the groups. However, weight was lower in group A (first tertile) vs. group B (second tertile) (p < 0.05). Also, BMI was lower in the group A vs. both group B and C (p < 0.05 and p < 0.01; respectively). In conclusion, our study points out to a poor reproducibility of the measurements of CCr in non-hospitalized subjects, especially in those with the high BMI.

Adult↗