Biomedical subjects

Zoltán Dienes

Publications and source records attributed to Zoltán Dienes.

6 recordsLinked to original sources

PubMed2006

Differences in the types of musical regularity learnt in incidental- and intentional-learning conditions.

Several studies have found learning of biconditional grammars only under intentional rule-search conditions (e.g., Johnstone & Shanks, 2001). Memorization of strings merely led to the learning of chunks. We used a musical grammar, a diatonic inversion, that is a type of biconditional grammar. Participants either were required to memorize a set of grammatical tunes (incidental learning), or were asked to search for the underlying rule whilst being given feedback about their performance (intentional learning). The results showed that participants in the incidental-learning condition did not learn the inversion rule and merely acquired explicit knowledge about chunks. However, participants in the intentional-learning condition learnt both the inversion rule and chunks.

Analysis of Variance↗

PubMed2005

Measuring unconscious knowledge: distinguishing structural knowledge and judgment knowledge.

This paper investigates the dissociation between conscious and unconscious knowledge in an implicit learning paradigm. Two experiments employing the artificial grammar learning task explored the acquisition of unconscious and conscious knowledge of structure (structural knowledge). Structural knowledge was contrasted to knowledge of whether an item has that structure (judgment knowledge). For both structural and judgment knowledge, conscious awareness was assessed using subjective measures. It was found that unconscious structural knowledge could lead to both conscious and unconscious judgment knowledge. When structural knowledge was unconscious, there was no tendency for judgment knowledge to become more conscious over time. Furthermore, conscious rather than unconscious structural knowledge produced more consistent errors in judgments, was facilitated by instructions to search for rules, and after such instructions was harmed by a secondary task. The dissociations validate the use of these subjective measures of conscious awareness.

Adult↗

PubMed2005

Implicit learning of nonlocal musical rules: implicitly learning more than chunks.

Dominant theories of implicit learning assume that implicit learning merely involves the learning of chunks of adjacent elements in a sequence. In the experiments presented here, participants implicitly learned a nonlocal rule, thus suggesting that implicit learning can go beyond the learning of chunks. Participants were exposed to a set of musical tunes that were all generated using a diatonic inversion. In the subsequent test phase, participants either classified test tunes as obeying a rule (direct test) or rated their liking for the tunes (indirect test). Both the direct and indirect tests were sensitive to knowledge of chunks. However, only the indirect test was sensitive to knowledge of the inversion rule. Furthermore, the indirect test was overall significantly more sensitive than the direct test, thus suggesting that knowledge of the inversion rule was below an objective threshold of awareness.

Cognition↗

PubMed2003

Developmental aspects of consciousness: how much theory of mind do you need to be consciously aware?

When do children become consciously aware of events in the world? Five possible strategies are considered for their usefulness in determining the age in question. Three of these strategies ask when children show signs of engaging in activities for which conscious awareness seems necessary in adults (verbal communication, executive control, explicit memory), and two of the strategies consider when children have the ability to have the minimal form of higher-order thought necessary for access consciousness and phenomenal consciousness, respectively. The tentative answer to the guiding question is that children become consciously aware between 12 and 15 months (+/-3 months).

Awareness↗

PubMed2003

Measuring learning using an untrained control group: comment on R. Reber and Perruchet.

R. Reber and Perruchet (this issue) argue that use of control groups without training is unsound for establishing that learning has occurred. We show that inferring learning from a difference between a trained group and an untrained control in no way relies on their implausible additivity assumption, and that untrained control groups can be an invaluable aid to the researcher.

Adult↗

PubMed1996

Asymmetric Synthesis and DNA Intercalation of (-)-6-[[(Aminoalkyl)oxy]methyl]-4-demethoxy-6,7- dideoxydaunomycinones(1)(,).

The BF(3).Et(2)O-promoted Diels-Alder addition of 1-acetylvinyl RADO(Et)-ate (RADO(Et)-ate = 3-ethyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-exo-carboxylate) to 1-(dimethoxymethyl)-2,3,5,6-tetramethylidene-7-oxabicyclo[2.2.1]heptane led to one major monoadduct that added to 1,2-didehydrobenzene and was converted into (-)-4-demethoxy-7-deoxydaunomycinone and (2R)-12-acetoxy-2-acetyl-5-(bromomethyl)-1,2,3,4-tetrahydronaphthacen-2-yl RADO(Et)-ate. The latter compound was used to construct (8R)-8-acetyl-6,8-dihydroxy-11-[[(3'-[(aminopropyl)oxy]-, -4'-[(aminobutyl)oxy], and -5'-[(aminopentyl)oxy]methyl]-7,8,9,10-tetrahydronaphthacene-5,12-dione hydrochloride (-)-8, (-)-9, (-)-10, respectively, as well as (8R)-8-acetyl-6,8-dihydroxy-11- [[[2'-[(3"-aminopropyl)amino]ethyl]oxy]- ((-)-11) and -[[3'-[(3"-aminopropyl)amino]propyl]oxy]methyl]-7,8,9, 10-tetrahydronaphthacene-5,12-dione hydrochloride ((-)-12). (8R)-8-Acetyl-6,8-dihydroxy-11-[[(alpha-L-daunosaminyl)oxy]methyl]-7,8,9,10-tetrahydronaphthacene-5,12-dione hydrochloride ((-)-13), a mimic of idarubicin, was also prepared. Absorbance and fluorescence titration experiments showed (-)-8, (-)-9, and (-)-10 to intercalate calf thymus DNA whereas (-)-11, (-)-12, and (-)-13 did not. The best intercalator was (-)-9 (K(b) = (1.1 +/- 0.1) x 10(5) M(-)(1)) with the [(4'-aminobutyl)oxy]methyl chain. Inhibition of topoisomerase II-induced DNA strand religation was observed for (-)-8 at a concentration of 50 &mgr;M.

Journal Article↗