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1,25-Dihydroxycholecalciferol increases bone resorption in thyroparathyroidectomised mice.

J J Reynolds·H Pavlovitch·S Balsan
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Abstract

Mice, 1 week old, prelabelled with 45Ca, were either thyroparathyroidectomised or sham-operated; 1 day later half of the mice of each group were injected with 1,25-dihydroxycholecalciferol (5 ng/g), and 20 h later all the mice were killed. Bone resorption in explants was then measured by an in vivo/in vitro technique previously published; compared with untreated mice it was found that 1,25-dihydroxycholecalciferol had increased resorption irrespective of whether the mice had been thyroparathyroidectomised or not. These data suggest that 1,25-dihydroxycholecalciferol is able to increase bone resorption independently of parathyroid hormone.

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AnimalsBone ResorptionDihydroxycholecalciferolsHydroxycholecalciferolsMiceParathyroid GlandsParathyroid HormoneThyroidectomyJournal Article

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J J Reynolds, H Pavlovitch, S Balsan. 1976-12-02. 1,25-Dihydroxycholecalciferol increases bone resorption in thyroparathyroidectomised mice.. https://doi.org/10.1007/bf02547397

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