How do peptide synthetases generate structural diversity?

D Konz; M A Marahiel

doi:10.1016/s1074-5521(99)80002-7

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PubMed · 10021423

How do peptide synthetases generate structural diversity?

D Konz·M A Marahiel

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Abstract

Many low-molecular-weight peptides of microbial origin are synthesized nonribosomally on large multifunctional proteins, termed peptide synthetases. These enzymes contain repeated building blocks in which several defined domains catalyze specific reactions of peptide synthesis. The order of these domains within the enzyme determines the sequence and structure of the peptide product.

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Animals Humans Peptide Biosynthesis Peptide Synthases Peptides Protein Conformation Journal Article Research Support, Non-U.S. Gov't Review

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D Konz, M A Marahiel. 1999. How do peptide synthetases generate structural diversity?. https://doi.org/10.1016/s1074-5521(99)80002-7

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