Multifocal osteosarcoma: an unusual presentation.

S Gunawardena; M Chintagumpala; L Trautwein; E Brewer; M V Gresik; M J Hicks; W R Harrison; A Morad; L D Cooley

PubMed · 10029815

Multifocal osteosarcoma: an unusual presentation.

S Gunawardena·M Chintagumpala·L Trautwein·E Brewer·M V Gresik·M J Hicks·W R Harrison·A Morad·L D Cooley

Abstract

PURPOSE: Report the unusual presentation, clinical course, and cytogenetic abnormalities in a child with multifocal osteosarcoma. PATIENTS AND METHODS: A 10-year-old boy had multifocal osteosarcoma involving the entire skeleton, pleura, bone marrow, and lungs. He had marked anemia, thrombocytopenia, and severe hypocalcemia at diagnosis. RESULTS: Despite aggressive chemotherapy, he died from progressive disease 1 month after diagnosis. Cytogenetic analysis of tumor cells within the pleural fluid showed multiple chromosomal abnormalities with amplification of the c-myc oncogene. CONCLUSION: Multifocal osteosarcoma should be considered in the differential diagnosis of a child with pancytopenia and multiple bone lesions. Amplification of the c-myc oncogene may have had a significant role in the pathogenesis, etiology, and rapid progression of this patient's multifocal disease. Additional studies will be needed to determine the biologic significance of c-myc amplification in multifocal osteosarcoma.

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BibTeX RIS

S Gunawardena, M Chintagumpala, L Trautwein, E Brewer, M V Gresik, M J Hicks, W R Harrison, A Morad, L D Cooley. Multifocal osteosarcoma: an unusual presentation.. https://pubmed.ncbi.nlm.nih.gov/10029815/

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