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PubMed · 10030769

Hydroxyurea to inhibit human immunodeficiency virus-1 replication.

F Romanelli·C Pomeroy·K M Smith
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Abstract

Treatment of human immunodeficiency virus (HIV) infection continues to be a challenge. Drug regimens that include two nucleoside reverse transcriptase inhibitors and a protease inhibitor are now the standard of care. These regimens require strict patient adherence and have numerous adverse effects at a high cost, so clinicians must continue to explore other therapeutic options. Hydroxyurea is a ribonucleotide reductase inhibitor that may have efficacy against HIV. We conducted a critical review of the literature to examine the utility of hydroxyurea-based drug combinations.

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Anti-HIV AgentsClinical Trials as TopicHIV InfectionsHIV-1HumansHydroxyureaVirus ReplicationJournal ArticleReview

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F Romanelli, C Pomeroy, K M Smith. 1999. Hydroxyurea to inhibit human immunodeficiency virus-1 replication.. https://doi.org/10.1592/phco.19.3.196.30913

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