Bacterial helicases.

E H Egelman

doi:10.1006/jsbi.1998.4050

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PubMed · 10049800

Bacterial helicases.

E H Egelman

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Abstract

Helicases are proteins that use the energy of ATP hydrolysis to open double-stranded DNA, RNA, or RNA-DNA hybrids into two single strands. Based upon sequence analysis, at least 12 helicases exist in Escherichia coli. We know that these proteins play important roles in DNA replication, recombination, repair, and transcription, as well as in RNA processing. Recent crystallographic studies have revealed a highly conserved catalytic core in the helicases, shared with the RecA protein and the F1-ATPase. However, evidence suggests that the functional divergence may be large.

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Bacteria Crystallography, X-Ray DNA Helicases DNA Repair DNA Replication Escherichia coli Models, Molecular Protein Conformation Protein Structure, Secondary Proton-Translocating ATPases RNA Helicases Rec A Recombinases Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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E H Egelman. 1998-12-15. Bacterial helicases.. https://doi.org/10.1006/jsbi.1998.4050

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