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PubMed · 10070898

Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.

A Vacca·D Ribatti·L Ruco·F Giacchetta·B Nico·F Quondamatteo·R Ria·M Iurlaro·F Dammacco
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Abstract

Node biopsies of 30 benign lymphadenopathies and 71 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for microvessel and macrophage counts using immunohistochemistry and morphometric analysis. Both counts were significantly higher in B-NHL. Moreover, when these were grouped into low-grade and high-grade lymphomas, according to the Kiel classification and Working Formulation (WF), statistically significant higher counts were found in the high-grade tumours. Immunohistochemistry and electron microscopy revealed a close spatial association between microvessels and macrophages. Overall, the results suggest that, in analogy to what has already been shown in solid tumours, angiogenesis occurring in B-NHLs increases with tumour progression, and that macrophages promote the induction of angiogenesis via the release of their angiogenic factors.

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Antigens, CDB-LymphocytesDisease ProgressionHumansHyperplasiaLymph NodesLymphatic DiseasesLymphoma, B-CellMacrophagesMicrocirculationNeoplasm StagingNeovascularization, PathologicRegression AnalysisT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov't

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A Vacca, D Ribatti, L Ruco, F Giacchetta, B Nico, F Quondamatteo, R Ria, M Iurlaro, F Dammacco. 1999. Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.. https://doi.org/10.1038/sj.bjc.6690154

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