PubMed · 10073632
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P C Donshik. 1999. A look back.. https://pubmed.ncbi.nlm.nih.gov/10073632/
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Introduced here are two predictive parameters, peDk/L and peDk. The prefix pe- (for physiologically effective) indicates that such values are estimates of lens transmissibility (Dk/L) and material permeability (Dk) and have been derived through a reverse application of the Residual Hypoxia model of Smith, relating corneal response (in hypoxic stress units) to lens transmissibility (Dk/L). Here, using independent databases, physiological responses to simple oxygen pathways (one layer, one material) but of unknown Dk value were entered into that model to estimate the Dk/L and (then by calculation) the Dk value of single vision rigid gas permeable (RGP) contact lenses. Also demonstrated was the application of this strategy for estimation of composite (integrated) Dk/L and Dk values of complex (multi-layer, multi-material) oxygen pathways, wherein one or more material Dk values and/or one or more local thickness are unknown.