T-cell development: What does Notch do for T cells?

H von Boehmer

doi:10.1016/s0960-9822(99)80110-9

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PubMed · 10074443

T-cell development: What does Notch do for T cells?

H von Boehmer

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Abstract

During their development, T cells are rescued from apoptotic cell death to follow distinct lineage fates. Recent data concerned with the role of the Notch transmembrane receptor in these events are interpreted to show that Notch promotes survival, but contrary to earlier reports has no function in lineage commitment.

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Animals Cell Differentiation Membrane Proteins Receptors, Antigen, T-Cell, alpha-beta Receptors, Antigen, T-Cell, gamma-delta Receptors, Notch T-Lymphocytes Journal Article Review

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H von Boehmer. 1999-03-11. T-cell development: What does Notch do for T cells?. https://doi.org/10.1016/s0960-9822(99)80110-9

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