PubMed Health⌕ Search

PubMed · 10076986

Reduced partial volume artifacts using spiral computed tomography and an integrating interpolator.

Abstract

A technique is described for obtaining computed tomography (CT) head images with significantly reduced partial volume artifacts while retaining excellent low contrast resolution. Partial volume artifacts could be reduced by narrowing the collimation and summing thin slices. However, in axial scans, the acquisition and reconstruction time required for generating all the thin slices would prove clinically impractical. In addition, image artifacts could occur due to patient motion during the scans, particularly in trauma cases. In the case of spiral CT, a narrow collimation along with a small pitch can be used to reduce partial volume artifacts. However, the time required to reconstruct and sum the thin slices is still prohibitive. In this paper, we present a spiral technique using an integrating spiral interpolator (ISI) that allows a head study to be performed in less time without the partial volume artifacts normally seen. Using this interpolator, thick slices can be prospectively reconstructed from a spiral scan with a narrow collimation. The slice sensitivity profile for this interpolator was obtained and the full width at half-maximum and full width at tenth-maximum values were compared with both axial and predicted values. Noise values were also measured and compared to axial and theoretical predictions. Using this ISI interpolator, high quality head images were obtained with significantly reduced partial volume artifacts compared to standard axial and spiral scans. Total acquisition time is less than that of standard contiguous axial head scans.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D J Heuscher, M Vembar. 1999. Reduced partial volume artifacts using spiral computed tomography and an integrating interpolator.. https://doi.org/10.1118/1.598523

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Striping artifact removal in VisiumHD data through nuclear counts modeling.

MOTIVATION: 10x Genomics VisiumHD enables spatial transcriptomics at 2 µm × 2 µm resolution but exhibits slide-specific, non-periodic striping artifacts due to lane-width variability. These multiplicative row/column effects distort bin total counts and can bias downstream analyses. The state-of-the-art destriping approach is the normalization procedure used as a preprocessing step in bin2cell; it applies sequential high-quantile row- then column-wise normalization, which is asymmetric and can introduce edge effects/macro-stripes and distortions of large-scale total-count structure. RESULTS: We propose a statistical destriping approach that leverages nuclei segmentation from the co-registered H&E image. Assuming transcript abundance is constant within each nucleus, we model bin counts with a negative binomial distribution whose mean is a product of a nucleus-specific concentration and row- and column-specific stripe-factors reflecting lane-width variation. We fit all parameters in a generalized linear modeling framework with cross-validated regularization on stripe-factors and iterative dispersion estimation, and use the fitted parameters to correct the observed counts into a destriped image. On synthetic data with known ground truth, our method improves stripe-factor estimation accuracy and reduces error in corrected counts relative to bin2cell and bin2cell-derived baselines. Across four public VisiumHD slides, it consistently lowers striping intensity while substantially better preserving biological signal present in the large-scale global count structure and avoiding the artifacts introduced by other methods. AVAILABILITY AND IMPLEMENTATION: All source code and links to publicly available data used for this study are available at https://github.com/paolamalsot/destriping-GLM.

Artifacts↗

Impairment of echocardiographic acoustic window caused by breast implants.

Cosmetic breast implants are increasing in popularity. The presence of a breast implant overlying the anterior mediastinal space as a cause of impairment of the echocardiographic acoustic window has not been described previously. Here, we report three cases with significant impairment of echocardiographic acoustic window caused by breast implants. Clinicians should be aware of this interference and women should be informed of this dilemma before considering this cosmetic surgery.

Artifacts↗