PubMed Health⌕ Search

PubMed · 10081039

[Abrasion arthroplasty].

Abstract

The removal of areas of chondromatous hyaline cartilage and the attempt to create new lod capacities for articular surfaces remain an encore in miscellaneous variations, pursued over decades in the last century. Recent research findings describe the biochemical interrelations and the three-dimensional structures of the collagenic matrix much more exactly. It was not until now a better insight into the metabolism and the dependent "state of aggregation" of the cartilage under changing mechanical exertion was made possible. From it prove, that the hyaline cartilage of the articulations represent a highly differentiated structure that is susceptible to mechanical and metabolic noxa and avails of remarkably minimal capability of regeneration. The results of repair are not within reach to approximate to functional ability of the original. This lights up that the amititious beginning to get to qualitative comparable regeneration by repair is not completed yet. Previous and furthermore differentiated and with restrictions of chondrocytes in compound with other protective and stimulating substances. Hitherto it seems advisable to refrain from steps being too active therapeutically. The unadulterated open abrasion of pathological articular cartilage has to be marked obsolete, today. Also the effect of abrasive arthroplasty, inductive character suggested, remains in the opinion of well-known authors in no proportion to expenditure of operation and rehabilitation and the expenses, because a sustaining success is not be expected in the long run, no matter whether drilling is done merely subcortical or subchondral, or use of spongiosa or microfracturing procedures. A more positive perspective in therapy appears with the holmium YAG-laser paving the way for gently treatment merely for degenerated cartilage: Regenerative beginnings to build hyaline cartilage have been reported. The abrasive arthroplasty probably will establish as a joint-conserving procedure in combination with the possibility of transplantation of chondrocyxtes to improve specific construction of the collagen matrix.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

V Goymann. 1999. [Abrasion arthroplasty].. https://doi.org/10.1007/s001320050316

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Dry reagent dipstick test combined with 23S rRNA PCR for molecular diagnosis of bacterial infection in arthroplasty.

Periprosthetic joint infections present a challenging problem in orthopaedics. Conventional methods for detection of arthroplasty infections rely on bacterial culture of synovial fluid aspirates. During recent years, however, molecular tests that are based on DNA amplification by the polymerase chain reaction (PCR), followed by electrophoretic analysis of the products, have been introduced. We report a simple and inexpensive assay that allows visual detection and confirmation of the PCR-amplified sequences by hybridization within minutes. The assay is performed in a dry reagent dipstick format (strip) and does not require special instrumentation. Universal primers are used for PCR of the 23S ribosomal RNA (rRNA) gene. The biotinylated amplification product is hybridized with dA-tailed probes that are specific for six pathogens commonly involved in periprosthetic joint infections. The mixture is applied to the strip, which is then immersed in the appropriate buffer. The buffer migrates along the strip by capillary action and rehydrates gold nanoparticles with oligo(dT) strands attached to their surface. The nanoparticles bind to the target DNA through hybridization, and the hybrids are captured by immobilized streptavidin at the test zone of the strip, producing a characteristic red line. Unbound nanoparticles are captured by immobilized oligo(dT) strands at the control zone of the strip, generating a second line. The dipstick test was applied to the detection of Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Enterococcus faesium, and Haemophilus influenza. Twelve samples of synovial fluids from patients were analyzed for the detection and identification of the infection caused by the six pathogens. The results were compared with bacterial cultures.

Arthroplasty↗