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PubMed · 10096871

Annonaceous acetogenins: recent progress.

F Q Alali·X X Liu·J L McLaughlin
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Abstract

The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.

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AnimalsAntineoplastic Agents, PhytogenicDrug Resistance, MicrobialDrug Resistance, MultipleFuransHumansLactonesPesticidesPlants, MedicinalJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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F Q Alali, X X Liu, J L McLaughlin. 1999. Annonaceous acetogenins: recent progress.. https://doi.org/10.1021/np980406d

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