Multiple gamma c-dependent cytokines regulate T-cell development.

T R Malek; B O Porter; Y W He

doi:10.1016/s0167-5699(98)01391-7

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PubMed · 10098325

Multiple gamma c-dependent cytokines regulate T-cell development.

T R Malek·B O Porter·Y W He

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Abstract

Mutations in the common gamma chain (gamma c) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. gamma c contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual gamma c-dependent cytokines in both conventional and intraepithelial T-cell development.

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Animals Antibodies, Monoclonal Cell Differentiation Hematopoiesis Humans Interleukins Mice Mice, Knockout Models, Immunological Receptors, Antigen, T-Cell, gamma-delta Receptors, Cytokine Receptors, Interleukin Severe Combined Immunodeficiency T-Lymphocyte Subsets Thymus Gland X Chromosome Journal Article Research Support, U.S. Gov't, P.H.S.Review

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T R Malek, B O Porter, Y W He. 1999. Multiple gamma c-dependent cytokines regulate T-cell development.. https://doi.org/10.1016/s0167-5699(98)01391-7

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