Dynamic reoptimization of a fed-batch fermentor.

M S Iyer; T F Wiesner; R R Rhinehart

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PubMed · 10099577

Dynamic reoptimization of a fed-batch fermentor.

M S Iyer·T F Wiesner·R R Rhinehart

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Abstract

Traditionally, fed-batch biochemical process optimization and control use complicated models and off-line optimizers with no on-line model adaptation and re-optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on-line re-optimization and control of an aerobic fed-batch fermentor.

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Animals Antibodies, Monoclonal Bioreactors Biotechnology Cell Culture Techniques Fermentation Humans Hybridomas Kinetics Models, Theoretical Reproducibility of Results Journal Article Research Support, Non-U.S. Gov't

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M S Iyer, T F Wiesner, R R Rhinehart. 1999-04-05. Dynamic reoptimization of a fed-batch fermentor.. https://pubmed.ncbi.nlm.nih.gov/10099577/

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