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PubMed · 1010949

Codominant inheritance in immunogenetic (IR-gene) systems.

A Ebringer·N J Deacon·C R Young
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Abstract

Immunogenetic (IR-gene) systems consist of animals showing different quantitative antibody responses when immunized with similar doses of a given antigen. Strains of animals giving high and low antibody titres are described as high and low responders, respectively. The degree of dominance in F1 hybrid strains, obtained from a cross between high and low responder parents, can readily be calculated using the dominance index formula, which takes the value of +1 for complete dominance, -1 for complete recessivity and the value of zero for no dominance. In reviewing 1527 F1 animals, obtained from ninety-one immunogenetic systems, the degree of diminance (d) was found to be: +0-0076 +/- 0-1053 (mean +/- s.e.), which is close to a value of zero and this is consistent with codominant inheritance. It is suggested that in immunogenetic systems, both alleles are expressed as codominant genes.

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AnimalsAntibodiesAntibody FormationGenes, DominantGuinea PigsHybridization, GeneticMiceRatsJournal Article

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A Ebringer, N J Deacon, C R Young. 1976. Codominant inheritance in immunogenetic (IR-gene) systems.. https://doi.org/10.1111/j.1744-313x.1976.tb00602.x

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