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PubMed · 10113869

AIDS legislation.

D Berke·E Battaglia
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Abstract

Significant and varied legislation relating to the AIDS crisis has been passed, and much remains pending for further debate. These measures, in various stages of the legislative process, affect PWAs and those who come into contact with the health care system.

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Acquired Immunodeficiency SyndromeAdultCommunicable Disease ControlFemaleFinancing, GovernmentHealth WorkforceHumansMalePatientsUnited StatesWomen's HealthJournal Article

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D Berke, E Battaglia. 1991. AIDS legislation.. https://pubmed.ncbi.nlm.nih.gov/10113869/

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The Env protein of human immunodeficiency virus type 1 is assembled into a stable trimer, and oligomerization is required for maintenance of viral infectivity. This property of Env suggests that Env mutants may have a dominant-negative effect on virus infectivity. To investigate this possibility, we established a packaging cell line in which both wild-type and mutant Env proteins could be expressed simultaneously in a single cell. We analyzed the effects of two types of Env mutants: cytoplasmic tail-truncated TM mutants and a mutant defective in gp120/gp41 cleavage. The cytoplasmic tail-truncated proteins were found to be incorporated into virions by forming an oligomer with wild-type TM, but could not inhibit the wild-type function. In contrast, phenotypic mixing of cleavage-defective Env with the wild-type protein caused dramatic inhibition of infectivity, indicating that this mutant has a strong dominant-negative phenotype.

Acquired Immunodeficiency Syndrome↗