PubMed · 10133152
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1994. Bits on bytes: computer-aided design software.. https://pubmed.ncbi.nlm.nih.gov/10133152/
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The development of new drugs with potential therapeutic applications is one of the most complex and difficult process in the pharmaceutical industry. Millions of dollars and man-hours are devoted to the discovery of new therapeutical agents. As, the activity of a drug is the result of a multitude of factors such as bioavailability, toxicity and metabolism, rational drug design has been utopias for centuries. Very recently, impressive technological advances in areas such as structural characterization of biomacromolecules, computer sciences and molecular biology have made rational drug design feasible. The aim of this review is to give an outline of studies in the field of medicinal chemistry in which molecular modeling has helped in the discovery process of new drugs. The emphasis will be on lead generation and optimization.
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One essential component of a successful lingual treatment concept is the precise calculation and manufacture of individual lingual arch wires. As in several parts of daily life, the use of modern CAD/CAM technology leads in lingual orthodontic treatment to a rationalisation of working processes with maximized precision. The lingual module developed by the author is a new scanner-independent procedure for calculation and manufacture of individual lingual arch wires with the Orthomate/Orthotherm system (OrthoTel, Berlin/Dallas, Tx). Especially the precise individualization of superelastic, shape-memory materials reduces the archwire sequence and simplifies lingual treatment considerably. Individual second and third order overcorrections (incisal torque, reverse curve of Spee) can be programmed into the first archwire, with further three-dimensional corrections being added for each single tooth during finishing. Embedded in a systematic treatment concept, the use of modern CAD/CAM technology for individual lingual archwire production with the Orthomate/Orthotherm system is an important aid to successful integration of lingual orthodontic treatment into routine practice.