A mechanical micro spray pump: an alternative to propellant driven devices?

R Jäger-Waldau; H Mehring; J D Wiggins

doi:10.1089/jam.1994.7.189

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A mechanical micro spray pump: an alternative to propellant driven devices?

R Jäger-Waldau·H Mehring·J D Wiggins

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Abstract

An account is given on the development of a purely mechanical Micro Spray Pump (MSP) which is capable of delivering aqueous drug solutions to the respiratory tract. In-vitro, deposition characteristics of two solutions, food dye and salbutamol sulphate, at different dosage levels and various flow rates were determined. A theoretical flow model was employed to understand deposition pattern in the Twin Impinger. In-vivo experiments where a 99mTc marked isotonic saline solution which nebulized by the MSP showed bronchial deposits on average of 8% and in a single experiment with spacer even up to 25%. The MSP prototype proves to be a feasible alternative non-propellant driven device to deliver drugs to the respiratory tract.

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R Jäger-Waldau, H Mehring, J D Wiggins. 1994. A mechanical micro spray pump: an alternative to propellant driven devices?. https://doi.org/10.1089/jam.1994.7.189

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