Development of small-diameter vascular prostheses which release bioactive agents.

G Soldani; M Steiner; P M Galletti; L Lelli; M Palla; P Giusti

doi:10.1016/0267-6605(91)90013-6

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PubMed · 10149151

Development of small-diameter vascular prostheses which release bioactive agents.

G Soldani·M Steiner·P M Galletti·L Lelli·M Palla·P Giusti

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Abstract

A porous, distensible, tubular membrane which incorporates albumin and basic Fibroblast Growth Factor (bFGF), and is potentially utilizable as a bioactive small-diameter vascular prosthesis, was fabricated by a combined spraying, phase-inversion technique using a suspension of albumin and bFGF into a polyetherurethane-urea (Biomer) solution in dimethylacetamide (DMA). Scanning electron microscopy showed a material with an open-cell trabecular structure and small particles of albumin and/or bFGF entrapped in the bulk of the polyurethane trabeculae. The material released albumin and bFGF at an approximately constant rate for at least 2 weeks. The bFGF initially incorporated in the polymer remained biologically active as shown by in-vitro proliferation of human endothelial cells.

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Albumins Biological Assay Blood Vessel Prosthesis Cell Division Endothelium, Vascular Fibroblast Growth Factors Humans Materials Testing Polyurethanes Prosthesis Design Journal Article Research Support, Non-U.S. Gov't

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G Soldani, M Steiner, P M Galletti, L Lelli, M Palla, P Giusti. 1991. Development of small-diameter vascular prostheses which release bioactive agents.. https://doi.org/10.1016/0267-6605(91)90013-6

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