PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 10166549

Migraine.

I C Matjucha·B Katz
View original source ↗Export metadata ↓

Abstract

Current research has focused on several aspects of migraine. Epidemiologic studies have described the general health characteristics of migraineurs. Case reports of unusual manifestations of migraine abound, and advances in the application of neurologic imaging offer the promise of prompt, efficient diagnosis of unusual vascular headaches. Investigations into physiologic and biochemical parameters of migraine continue to advance theories of pathogenesis. Finally, as a wide range of therapeutic modalities continue to be used in these diseases, the efficacy, complications, and relative costs of different therapies are discussed.

Explore related subjects

Combined Modality TherapyCost-Benefit AnalysisHumansMigraine DisordersJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

I C Matjucha, B Katz. 1996. Migraine.. https://doi.org/10.1097/00055735-199612000-00002

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2002

Mental practice.

Explore the source record for details and available documents.

Combined Modality Therapy↗
PubMed2002

Synergistic cell-killing effect of a combination of hyperthermia and heavy ion beam irradiation: in expectation of a breakthrough in the treatment of refractory cancers (review).

We studied the sensitivity against heavy ion beam and hyperthermia on radioresistant procaryote, Deinococcus radiodurans, for the purpose of cancer therapy. First, we examined the decrease of the survival rate and molecular weight of DNA purified from this cell by acid heat treatment. These decreases were recognized by heating at 55 degrees C below pH 5.0. Then, we assumed that the decrease in survival of D. radiodurans in vivo and damage to its DNA in vitro by acid heating were due to the release of purine rings from the phosphodiester backbone of DNA molecules, i.e., depurination. Second, we investigated the relation between LET (linear energy transfer) and RBE (relative biological effectiveness) on D. radiodurans dry and wet cells using AVF cyclotron at the TIARA facility of JAERI-Takasaki, Japan. These cells were irradiated with carbon (12C5+) ion beam at LET of about 100 keV/microm, neon (20Ne8+) ion beam at LET of about 300 keV/microm and oxygen (16O6+) ion beam at LET of about 400 keV/microm. The peak in the figure of the relation between LET and RBE value was found to increase according to the increase of LET value from 100 keV/microm. Third, we conducted combination treatment with 4.8 kGy of alpha-particles, i.e., boron 10 neutron captured beam induced by Kyoto University Research Nuclear Reactor operated at 5 MW, and hyperthermia at 52 degrees C, which caused the synergistic killing effect on D. radiodurans wet cells. However, being dissimilar to the case of gamma-irradiation, the interval incubation at 30 degrees C in the medium between both treatments could inhibit the recovery of survival.

Combined Modality Therapy↗