Improving the ethylene oxide sterilization process.

Abstract

Although ethylene oxide (EtO) sterilization is commonly used in the manufacture of sterile medical devices, concern about residues of the sterilant in the sterilized products has led to an increase in the use of alternative methods; however, these methods, in turn, have significant drawbacks. The authors have tackled the issue by looking into the possibility of reducing EtO residuals. After conducting a series of investigative experiments, it has been proved that EtO residuals may be reduced by decreasing the amount of EtO used in the sterilization process. This can be achieved without lowering the safe sterility level and there are additional benefits for safety, cost, and the environment.