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PubMed · 10174692

Hematopoietic stem cell expansion.

A Rice·J Ripoche·J Reiers
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Abstract

This review addresses two issues: (1) cytokine-mediated expansion of functional end cells for the abrogation of short term neutropenia and thrombopenia following high dose chemotherapy and (2) cytokine-driven increase in absolute numbers of functional stem cells. The literature suggests that the short term exposure of CD34+ cells to cytokines produces mature progenitors which in turn give rise to functional neutrophils and platelets. The expansion of functional stem cells is a more complex issue, as primitive stem cells are quiescent and their growth requirements are less clearly defined.

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AnimalsAntigens, CD34Blood Cell CountCell DifferentiationCytokinesHematopoietic Stem CellsHumansJournal ArticleReview

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A Rice, J Ripoche, J Reiers. 1997. Hematopoietic stem cell expansion.. https://doi.org/10.1016/s0955-3886(97)00019-2

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