PubMed · 101875
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N K Mello. 1978. Control of drug self-administration: the role of aversive consequences.. https://pubmed.ncbi.nlm.nih.gov/101875/
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Following rapid isolation, it has been found that Golgi apparatus from ethanol-intoxicated animals contain high levels of galactosyltransferase but also detectable glucose-6-phosphatase and microsomal esterase, as well as 5'-nucleotidase activity. In experiments carried out in parallel on littermate animals but without intoxication, similar recoveries and specific activities of the four enzymes were observed. Morphologic analysis of Golgi fractions isolated from control animals demonstrated no striking morphologic difference to those from the ethanol-intoxicated animals. Indeed, using galloyl glucose-lead staining techniques to mark the lipoprotein particles in situ, it was found that all Golgi apparatus of hepatocytes from control animals were marked by very low density lipoprotein particles. It is therefore concluded that within the limits of the present analyses, Golgi fractions isolated from control animals are as valid as those isolated from ethanol-intoxicated rats.
Four components of 20 degrees horizontal saccadic eye movements, i.e., latency, mean and maximum velocities, and duration were measured in 16 students under the influence of alcohol and also in a control situation. The experimental procedures were standardized and automated as much as possible. Latency (simple eye reaction time) was not influenced by alcohol in blood concentrations of 0.056--0.116%. Mean and maximum eye velocities decreased by about 9% and duration of saccades increased by 11%. The maximum changes occurred 90--120 min after the start of alcohol ingestion. The changes in velocities and durations correlated more closely with feelings of intoxication than with blood alcohol concentrations. There were great intra- and intersubject variations in reactions to alcohol. The close resemblance between the effects of certain psychotropic drugs, alcohol, fatigue, and decreased attention on eye movement control suggest that all these may act upon the same nervous structures in the brain stem.