Programmed cell death and the caspases.

G S Salvesen

doi:10.1111/j.1699-0463.1999.tb01528.x

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Programmed cell death and the caspases.

G S Salvesen

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Abstract

Members of a family of cysteine proteases known as caspases orchestrate the intracellular biochemical events that enable animal cells to kill themselves by apoptosis. To counteract the apoptotic response to infection, some viruses have adapted and evolved proteins that specifically block caspases. More recently, it has been demonstrated that endogenous proteins belonging to the IAP family can regulate apoptosis by directly inactivating some of the caspases involved in initiating and executing programmed cell death.

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Animals Apoptosis Caspase Inhibitors Caspases Enzyme Activation Enzyme Precursors Humans Proteins X-Linked Inhibitor of Apoptosis Protein Journal Article Research Support, U.S. Gov't, P.H.S.Review

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G S Salvesen. 1999. Programmed cell death and the caspases.. https://doi.org/10.1111/j.1699-0463.1999.tb01528.x

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