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PubMed · 10190283

Proteolytic control of growth factor availability.

D B Rifkin·R Mazzieri·J S Munger·I Noguera·J Sung
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Abstract

Most growth factors are released from cells in a form that does not permit immediate interaction with their high affinity receptors. An important mechanism for presentation of these released latent growth factors is activation by the plasminogen activator-plasmin system. The involvement of this system in the biology of Transforming Growth Factor-beta (TGF-beta) is reviewed.

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AnimalsCarrier ProteinsFibrinolysinHumansIntracellular Signaling Peptides and ProteinsLatent TGF-beta Binding ProteinsPlasminogen ActivatorsTransforming Growth Factor betaJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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D B Rifkin, R Mazzieri, J S Munger, I Noguera, J Sung. 1999. Proteolytic control of growth factor availability.. https://doi.org/10.1111/j.1699-0463.1999.tb01529.x

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