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PubMed · 1019052

[Eosinophils: their structure, function and clinical evaluation].

A Szczeklik·J Musial·R Pietoń
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EosinophiliaEosinophilsHumansImmunity, CellularLeukemiaPhagocytosisPulmonary EosinophiliaJournal Article

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A Szczeklik, J Musial, R Pietoń. 1976. [Eosinophils: their structure, function and clinical evaluation].. https://pubmed.ncbi.nlm.nih.gov/1019052/

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Nonallergic rhinitis with eosinophilia syndrome and related disorders.

NARES is a clinical syndrome consisting of symptoms consistent with AR in which an absence of atopy has been demonstrated by allergen skin testing, with nasal cytology analysis showing greater than 20% eosinophils. Anosmia is a prominent feature not shared with AR. The pathophysiology of NARES is poorly understood, but a key component involves a self-perpetuating, chronic eosinophilic nasal inflammation with development of nasal micropolyposis and polyposis. Mast cells likely play an important role as well. NARES is a risk factor for the development of nasal polyposis and aspirin sensitivity, as well as obstructive sleep apnea. Treatment consists mainly of intranasal corticosteroids with or without the addition of second-generation antihistamines and/or LT receptor antagonists as an adjuvant.

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